Muscarinic acetylcholine receptors in Alzheimer's disease. In vivo imaging with iodine 123-labeled 3-quinuclidinyl-4-iodobenzilate and emission tomography
In vivo imaging of muscarinic acetylcholine receptor binding function in a patient with Alzheimer's disease, using single-photon emission computed tomography and iodine ST-labeled 3-quinuclidinyl-4-iodobenzilate ( STI-QNB), and perfusion imaging using STI-N-isopropyl p-iodoamphetamine are described. A profound decrease in perfusion to the posterior temporal and parietal cortex and a more uniform uptake of STI-QNB throughout the cerebral cortex were observed. The STI-QNB activity ratio was reduced compared with that of a normal age-matched subject, suggesting a moderate impairment in muscarinic receptor binding function in Alzheimer's disease. Furthermore, and more importantly, our study demonstrates that images of in vivo receptor binding can be obtained easily and nontraumatically using STI-QNB and single-photon emission computed tomography.
- Research Organization:
- Brigham and Women's Hospital, Boston, MA
- OSTI ID:
- 6234660
- Journal Information:
- JAMA, J. Am. Med. Assoc.; (United States), Vol. 21
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
BRAIN
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
HYDROXY ACIDS
DIAGNOSTIC USES
IODINE 123
ACETYLCHOLINE
AMPHETAMINES
PERFUSED TISSUES
AMINES
AMMONIUM COMPOUNDS
ANALEPTICS
ANIMAL TISSUES
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM AGENTS
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
ESTERS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
NERVOUS SYSTEM
NEUROREGULATORS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PARASYMPATHOMIMETICS
QUATERNARY COMPOUNDS
RADIOISOTOPES
SYMPATHOMIMETICS
TISSUES
TOMOGRAPHY
USES
550601* - Medicine- Unsealed Radionuclides in Diagnostics