Syntheses, kinetics, and mechanism of formation of polynuclear hydroxo-bridged complexes of (trans-1,2-diaminocyclohexane)platinum(II)

Journal Article · Wed Aug 25 00:00:00 EDT 1982 · J. Am. Chem. Soc.; (United States)

DOI:https://doi.org/10.1021/ja00381a016· OSTI ID:6234632

Gill, D S; Rosenberg, B

The synthesis and /sup 195/Pt chemical shifts of the hydroxo-bridged dimer and trimer, isolated form an aquated solution of bis(nitrato)(trans-1,2-diaminocyclohexane)platinum (I), at different pH are described. The chemical shifts of these three complexes are widely separated, and /sup 195/Pt NMR provides a convenient method for the investigation of dimer formation kinetics from I. Rate constants for the dimerization reaction calculated at different pD, temperature, and concentration agree well with the hypothesis that dimerization occurs with a rate-limiting bimolecular reaction of an intermediate hydroxo species formed by the loss of a proton from the parent complex.

• OSTI ID: 6234632
• Journal Information: J. Am. Chem. Soc.; (United States), Vol. 104:17
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC
ORGANIC
PHYSICAL AND ANALYTICAL CHEMISTRY
62 RADIOLOGY AND NUCLEAR MEDICINE
PLATINUM COMPLEXES
CHEMICAL PREPARATION
CHEMICAL SHIFT
CHEMICAL REACTION KINETICS
DIMERIZATION
ORGANIC NITROGEN COMPOUNDS
PLATINUM 195
CHEMICAL REACTIONS
COMPLEXES
DAYS LIVING RADIOISOTOPES
EVEN-ODD NUCLEI
HEAVY NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KINETICS
NUCLEI
ORGANIC COMPOUNDS
PLATINUM ISOTOPES
POLYMERIZATION
RADIOISOTOPES
REACTION KINETICS
STABLE ISOTOPES
SYNTHESIS
TRANSITION ELEMENT COMPLEXES
400301* - Organic Chemistry- Chemical & Physicochemical Properties- (-1987)
550601 - Medicine- Unsealed Radionuclides in Diagnostics