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Title: Soft-tissue reactions following irradiation of primary brain and pituitary tumors

Abstract

One hundred and ninety-nine patients who received radiation therapy for a primary brain or pituitary tumor were studied for radiation-induced soft-tissue reactions of the cranium, scalp, ears and jaw. The frequency of these reactions was studied as a function of: the radiation dose 5 mm below the skin surface, dose distribution, field size and fraction size. Forty percent of patients had complete and permanent epilation, while 21% had some other soft-tissue complication, including: scalp swelling-6%, external otitis-6%, otitis media-5%, ear swelling-4%, etc. The frequency of soft-tissue reactions correlates directly with the radiation dose at 5 mm below the skin surface. Patients treated with small portals (<70 cm/sup 2/) had few soft-tissue reactions. The dose to superficial tissues, and hence the frequency of soft-tissue reactions can be reduced by: (1) using high-energy megavoltage beams; (2) using equal loading of beams; and (3) possibly avoiding the use of electron beams.

Authors:
;
Publication Date:
Research Org.:
Washington Univ. School of Medicine, St. Louis, MO
OSTI Identifier:
6232032
Resource Type:
Conference
Journal Name:
Int. J. Radiat. Oncol., Biol. Phys.; (United States)
Additional Journal Information:
Journal Volume: 7:4; Conference: ASTR meeting, New Orleans, LA, USA, Oct 1979
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 62 RADIOLOGY AND NUCLEAR MEDICINE; AUDITORY ORGANS; BIOLOGICAL RADIATION EFFECTS; EPILATION; RADIOINDUCTION; JAW; RADIOTHERAPY; SIDE EFFECTS; SKIN; BRAIN; NEOPLASMS; PARTIAL BODY IRRADIATION; PATIENTS; PITUITARY GLAND; RADIATION DOSE DISTRIBUTIONS; RADIATION DOSES; BIOLOGICAL EFFECTS; BODY; CENTRAL NERVOUS SYSTEM; DISEASES; DOSES; ENDOCRINE GLANDS; EXTERNAL IRRADIATION; GLANDS; IRRADIATION; MEDICINE; NERVOUS SYSTEM; NUCLEAR MEDICINE; ORGANS; PATHOLOGICAL CHANGES; RADIATION EFFECTS; RADIOLOGY; SENSE ORGANS; SKELETON; SKULL; THERAPY; 560151* - Radiation Effects on Animals- Man; 550603 - Medicine- External Radiation in Therapy- (1980-)

Citation Formats

Baglan, R.J., and Marks, J.E. Soft-tissue reactions following irradiation of primary brain and pituitary tumors. United States: N. p., 1981. Web.
Baglan, R.J., & Marks, J.E. Soft-tissue reactions following irradiation of primary brain and pituitary tumors. United States.
Baglan, R.J., and Marks, J.E. Wed . "Soft-tissue reactions following irradiation of primary brain and pituitary tumors". United States.
@article{osti_6232032,
title = {Soft-tissue reactions following irradiation of primary brain and pituitary tumors},
author = {Baglan, R.J. and Marks, J.E.},
abstractNote = {One hundred and ninety-nine patients who received radiation therapy for a primary brain or pituitary tumor were studied for radiation-induced soft-tissue reactions of the cranium, scalp, ears and jaw. The frequency of these reactions was studied as a function of: the radiation dose 5 mm below the skin surface, dose distribution, field size and fraction size. Forty percent of patients had complete and permanent epilation, while 21% had some other soft-tissue complication, including: scalp swelling-6%, external otitis-6%, otitis media-5%, ear swelling-4%, etc. The frequency of soft-tissue reactions correlates directly with the radiation dose at 5 mm below the skin surface. Patients treated with small portals (<70 cm/sup 2/) had few soft-tissue reactions. The dose to superficial tissues, and hence the frequency of soft-tissue reactions can be reduced by: (1) using high-energy megavoltage beams; (2) using equal loading of beams; and (3) possibly avoiding the use of electron beams.},
doi = {},
journal = {Int. J. Radiat. Oncol., Biol. Phys.; (United States)},
number = ,
volume = 7:4,
place = {United States},
year = {1981},
month = {4}
}

Conference:
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