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Title: Nuclear Medicine Program progress report for quarter ending September 30, 1990

Abstract

An evaluation of the Oak Ridge National Laboratory (ORNL) alumina-based tungsten-188/rhenium-188 (W-188/Re-188) generator system has continued. Our goal is to develop a prototype system which will provide sufficient levels of Re-188 for radiolabeling of tumor-specific antibodies for radioimmunotherapy. During this review period several samples were supplied for collaborative studies. Samples of rhenium-188 from the ORNL W-188/Re-188 generators were supplied to the National Institutes of Standards and Technology (NIST) as a calibration standard. Iodine-125-labeled IMP protein labeling agent was supplied to the University of Michigan for antibody radiolabeling studies (D. Buchsbaum, Ph.D.). The iodine-123-labeled BMIPP fatty acid analogue developed at ORNL was also supplied to collaborators at BNL for SPECT imaging studies of the effects of cocaine intoxication on myocardial fatty acid uptake in a canine model. Iodine-125-BMIPP was also supplied to the University of Bonn, Germany for continuing metabolic studies in an isolated heart model. In this report the resumption of radioisotope production in the HFIR following the restart of this important facility in July 1990 and the preparation and review and evaluation of issues for the DOE Tiger Team visit to ORNL on November 1--December 7 are also discussed. 2 figs., 1 tab.

Authors:
; ; ; ; ; ; ; ; ; ;
Publication Date:
Research Org.:
Oak Ridge National Lab., TN (USA)
Sponsoring Org.:
DOE/DP
OSTI Identifier:
6228890
Report Number(s):
ORNL/TM-11721
ON: DE91007663
DOE Contract Number:  
AC05-84OR21400
Resource Type:
Technical Report
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY; ANTIBODIES; LABELLING; CARBOXYLIC ACIDS; IODINATION; RADIOPHARMACEUTICALS; SYNTHESIS; BIOLOGICAL EFFECTS; COCAINE; DOGS; HFIR REACTOR; IODINE 123; IODINE 135; METABOLISM; NUCLEAR MEDICINE; PROGRESS REPORT; RADIOIMMUNOTHERAPY; RADIOISOTOPE GENERATORS; RHENIUM 188; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; TUNGSTEN 188; UPTAKE; ALKALOIDS; ANESTHETICS; ANIMALS; ANTIDEPRESSANTS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CENTRAL NERVOUS SYSTEM AGENTS; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CHEMICAL REACTIONS; COMPUTERIZED TOMOGRAPHY; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DOCUMENT TYPES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; EMISSION COMPUTED TOMOGRAPHY; ENRICHED URANIUM REACTORS; EVEN-EVEN NUCLEI; HALOGENATION; HEAVY NUCLEI; HOURS LIVING RADIOISOTOPES; IMMUNOLOGY; IMMUNOTHERAPY; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; IODINE ISOTOPES; IRRADIATION REACTORS; ISOMERIC TRANSITION ISOTOPES; ISOTOPE PRODUCTION REACTORS; ISOTOPES; LABELLED COMPOUNDS; MAMMALS; MEDICINE; MINUTES LIVING RADIOISOTOPES; NUCLEI; ODD-EVEN NUCLEI; ODD-ODD NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; PSYCHOTROPIC DRUGS; RADIOIMMUNOLOGY; RADIOISOTOPES; RADIOLOGY; RADIOTHERAPY; REACTORS; RESEARCH AND TEST REACTORS; RESEARCH REACTORS; RHENIUM ISOTOPES; TANK TYPE REACTORS; TEST REACTORS; THERAPY; THERMAL REACTORS; TOMOGRAPHY; TUNGSTEN ISOTOPES; VERTEBRATES; WATER COOLED REACTORS; WATER MODERATED REACTORS; 550601* - Medicine- Unsealed Radionuclides in Diagnostics; 400703 - Radiochemistry & Nuclear Chemistry- Radioisotope Production

Citation Formats

Knapp, Jr, F F, Ambrose, K R, Callahan, A P, McPherson, D W, Mirzadeh, S, Srivastava, P C, Allred, J F, Hasan, A, Lambert, C R, Lambert, S J, and Rice, D E. Nuclear Medicine Program progress report for quarter ending September 30, 1990. United States: N. p., 1991. Web.
Knapp, Jr, F F, Ambrose, K R, Callahan, A P, McPherson, D W, Mirzadeh, S, Srivastava, P C, Allred, J F, Hasan, A, Lambert, C R, Lambert, S J, & Rice, D E. Nuclear Medicine Program progress report for quarter ending September 30, 1990. United States.
Knapp, Jr, F F, Ambrose, K R, Callahan, A P, McPherson, D W, Mirzadeh, S, Srivastava, P C, Allred, J F, Hasan, A, Lambert, C R, Lambert, S J, and Rice, D E. Fri . "Nuclear Medicine Program progress report for quarter ending September 30, 1990". United States.
@article{osti_6228890,
title = {Nuclear Medicine Program progress report for quarter ending September 30, 1990},
author = {Knapp, Jr, F F and Ambrose, K R and Callahan, A P and McPherson, D W and Mirzadeh, S and Srivastava, P C and Allred, J F and Hasan, A and Lambert, C R and Lambert, S J and Rice, D E},
abstractNote = {An evaluation of the Oak Ridge National Laboratory (ORNL) alumina-based tungsten-188/rhenium-188 (W-188/Re-188) generator system has continued. Our goal is to develop a prototype system which will provide sufficient levels of Re-188 for radiolabeling of tumor-specific antibodies for radioimmunotherapy. During this review period several samples were supplied for collaborative studies. Samples of rhenium-188 from the ORNL W-188/Re-188 generators were supplied to the National Institutes of Standards and Technology (NIST) as a calibration standard. Iodine-125-labeled IMP protein labeling agent was supplied to the University of Michigan for antibody radiolabeling studies (D. Buchsbaum, Ph.D.). The iodine-123-labeled BMIPP fatty acid analogue developed at ORNL was also supplied to collaborators at BNL for SPECT imaging studies of the effects of cocaine intoxication on myocardial fatty acid uptake in a canine model. Iodine-125-BMIPP was also supplied to the University of Bonn, Germany for continuing metabolic studies in an isolated heart model. In this report the resumption of radioisotope production in the HFIR following the restart of this important facility in July 1990 and the preparation and review and evaluation of issues for the DOE Tiger Team visit to ORNL on November 1--December 7 are also discussed. 2 figs., 1 tab.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1991},
month = {2}
}

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