Nuclear Medicine Program progress report for quarter ending September 30, 1990
An evaluation of the Oak Ridge National Laboratory (ORNL) alumina-based tungsten-188/rhenium-188 (W-188/Re-188) generator system has continued. Our goal is to develop a prototype system which will provide sufficient levels of Re-188 for radiolabeling of tumor-specific antibodies for radioimmunotherapy. During this review period several samples were supplied for collaborative studies. Samples of rhenium-188 from the ORNL W-188/Re-188 generators were supplied to the National Institutes of Standards and Technology (NIST) as a calibration standard. Iodine-125-labeled IMP protein labeling agent was supplied to the University of Michigan for antibody radiolabeling studies (D. Buchsbaum, Ph.D.). The iodine-123-labeled BMIPP fatty acid analogue developed at ORNL was also supplied to collaborators at BNL for SPECT imaging studies of the effects of cocaine intoxication on myocardial fatty acid uptake in a canine model. Iodine-125-BMIPP was also supplied to the University of Bonn, Germany for continuing metabolic studies in an isolated heart model. In this report the resumption of radioisotope production in the HFIR following the restart of this important facility in July 1990 and the preparation and review and evaluation of issues for the DOE Tiger Team visit to ORNL on November 1--December 7 are also discussed. 2 figs., 1 tab.
- Research Organization:
- Oak Ridge National Lab., TN (USA)
- Sponsoring Organization:
- DOE/DP
- DOE Contract Number:
- AC05-84OR21400
- OSTI ID:
- 6228890
- Report Number(s):
- ORNL/TM-11721; ON: DE91007663
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
ANTIBODIES
LABELLING
CARBOXYLIC ACIDS
IODINATION
RADIOPHARMACEUTICALS
SYNTHESIS
BIOLOGICAL EFFECTS
COCAINE
DOGS
HFIR REACTOR
IODINE 123
IODINE 135
METABOLISM
NUCLEAR MEDICINE
PROGRESS REPORT
RADIOIMMUNOTHERAPY
RADIOISOTOPE GENERATORS
RHENIUM 188
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
TUNGSTEN 188
UPTAKE
ALKALOIDS
ANESTHETICS
ANIMALS
ANTIDEPRESSANTS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CENTRAL NERVOUS SYSTEM AGENTS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
CHEMICAL REACTIONS
COMPUTERIZED TOMOGRAPHY
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DOCUMENT TYPES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
ENRICHED URANIUM REACTORS
EVEN-EVEN NUCLEI
HALOGENATION
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
IMMUNOLOGY
IMMUNOTHERAPY
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IODINE ISOTOPES
IRRADIATION REACTORS
ISOMERIC TRANSITION ISOTOPES
ISOTOPE PRODUCTION REACTORS
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MEDICINE
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
PSYCHOTROPIC DRUGS
RADIOIMMUNOLOGY
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
REACTORS
RESEARCH AND TEST REACTORS
RESEARCH REACTORS
RHENIUM ISOTOPES
TANK TYPE REACTORS
TEST REACTORS
THERAPY
THERMAL REACTORS
TOMOGRAPHY
TUNGSTEN ISOTOPES
VERTEBRATES
WATER COOLED REACTORS
WATER MODERATED REACTORS
550601* - Medicine- Unsealed Radionuclides in Diagnostics
400703 - Radiochemistry & Nuclear Chemistry- Radioisotope Production