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Title: Urinary trimethylselenonium excretion by the rat: effect of level and source of /sup 75/Se

Abstract

The purpose of this study was to explore in rats the urinary metabolites of selenium (Se), by using (/sup 75/Se)selenomethionine, (/sup 75/Se)selenocystine, and (/sup 75/Se)selenite, and to assess the effects of low and high levels of Se intake on trimethylselenonium ion (TMSe) excretion in urine. Male adult rats were adapted for 6 weeks to a commercial rat laboratory stock diet (0.25 ppm Se). They were then starved for 24 hours and given an oral dose of either low (16 micrograms Se/kg body weight) or high (1500 micrograms Se/kg body weight) Se as the test Se compounds. Appearance of radioactivity in TMSe and non-TMSe Se metabolites in urine was monitored for 48 hours. About 40% of the /sup 75/Se dose was excreted in urine. TMSe was the major urinary Se metabolite (57-69% of urinary /sup 75/Se and 16-25% of oral /sup 75/Se dose) at high, and a minor urinary Se metabolite (10% of urinary /sup 75/Se and 3-4% of oral /sup 75/Se dose) at low dose levels of Se and for all three Se test compounds. At least 80% of urinary /sup 75/Se and 26-42% of the orally administered /sup 75/Se were excreted as non-TMSe Se metabolites in urine under themore » latter condition. It is hypothesized that at a requirement intake of Se either a trace or no TMSe is excreted in urine, and it becomes a major excretory metabolite of Se when the dietary trace mineral intake exceeds a requirement level, probably serving as a means of detoxification.« less

Authors:
; ;
Publication Date:
Research Org.:
Laboratory of Human Nutrition, Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge
OSTI Identifier:
6217684
Resource Type:
Journal Article
Journal Name:
J. Nutr.; (United States)
Additional Journal Information:
Journal Volume: 113:2
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 59 BASIC BIOLOGICAL SCIENCES; SELENIUM; METABOLISM; SELENIUM 75; CYSTINE; DIET; EXCRETION; METABOLITES; METHIONINE; RADIONUCLIDE KINETICS; RATS; TRACER TECHNIQUES; URINE; AMINO ACIDS; ANIMALS; BETA DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BIOLOGICAL WASTES; BODY FLUIDS; CARBOXYLIC ACIDS; CLEARANCE; DAYS LIVING RADIOISOTOPES; DISULFIDES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; ELEMENTS; EVEN-ODD NUCLEI; INTERMEDIATE MASS NUCLEI; ISOTOPE APPLICATIONS; ISOTOPES; LIPOTROPIC FACTORS; MAMMALS; MATERIALS; NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC SULFUR COMPOUNDS; RADIOISOTOPES; RODENTS; SELENIUM ISOTOPES; SEMIMETALS; VERTEBRATES; WASTES; 560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987); 550501 - Metabolism- Tracer Techniques

Citation Formats

Nahapetian, A T, Janghorbani, M, and Young, V R. Urinary trimethylselenonium excretion by the rat: effect of level and source of /sup 75/Se. United States: N. p., 1983. Web.
Nahapetian, A T, Janghorbani, M, & Young, V R. Urinary trimethylselenonium excretion by the rat: effect of level and source of /sup 75/Se. United States.
Nahapetian, A T, Janghorbani, M, and Young, V R. Tue . "Urinary trimethylselenonium excretion by the rat: effect of level and source of /sup 75/Se". United States.
@article{osti_6217684,
title = {Urinary trimethylselenonium excretion by the rat: effect of level and source of /sup 75/Se},
author = {Nahapetian, A T and Janghorbani, M and Young, V R},
abstractNote = {The purpose of this study was to explore in rats the urinary metabolites of selenium (Se), by using (/sup 75/Se)selenomethionine, (/sup 75/Se)selenocystine, and (/sup 75/Se)selenite, and to assess the effects of low and high levels of Se intake on trimethylselenonium ion (TMSe) excretion in urine. Male adult rats were adapted for 6 weeks to a commercial rat laboratory stock diet (0.25 ppm Se). They were then starved for 24 hours and given an oral dose of either low (16 micrograms Se/kg body weight) or high (1500 micrograms Se/kg body weight) Se as the test Se compounds. Appearance of radioactivity in TMSe and non-TMSe Se metabolites in urine was monitored for 48 hours. About 40% of the /sup 75/Se dose was excreted in urine. TMSe was the major urinary Se metabolite (57-69% of urinary /sup 75/Se and 16-25% of oral /sup 75/Se dose) at high, and a minor urinary Se metabolite (10% of urinary /sup 75/Se and 3-4% of oral /sup 75/Se dose) at low dose levels of Se and for all three Se test compounds. At least 80% of urinary /sup 75/Se and 26-42% of the orally administered /sup 75/Se were excreted as non-TMSe Se metabolites in urine under the latter condition. It is hypothesized that at a requirement intake of Se either a trace or no TMSe is excreted in urine, and it becomes a major excretory metabolite of Se when the dietary trace mineral intake exceeds a requirement level, probably serving as a means of detoxification.},
doi = {},
url = {https://www.osti.gov/biblio/6217684}, journal = {J. Nutr.; (United States)},
number = ,
volume = 113:2,
place = {United States},
year = {1983},
month = {2}
}