Inhalation developmental toxicology studies: Teratology study of isoprene in mice and rats: Final report
Isoprene, a reactive, branched diene, is used in large quantities in the manufacture of polyisoprene and as a copolymer in the synthesis of butyl rubber. The potential for isoprene to cause developmental toxicity was assessed in rodents, by exposing four groups each of Sprague-Dawley rats and Swiss (CD-1) mice to 0, 280, 1400, or 7000 ppM isoprene vapors, 6 h/day, 7 day/wk. Each treatment group consisted of 10 virgin females (for comparison), and approx.30 positively mated rats or mice. Positively mated mice were exposed on days 6-17 of gestation (dg), and rats on 6-19 dg. The day of plug or sperm detection was designated as 0 dg. Body weights were obtained throughout the study period, and uterine and fetal body weights were obtained at sacrifice (rats, 20 dg; mice, 18 dg). Implants were enumerated and their status recorded. Live fetuses were sexed and examined for gross, visceral, skeletal, and soft-tissue craniofacial defects. 31 refs., 6 figs., 19 tabs.
- Research Organization:
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
- DOE Contract Number:
- AC06-76RL01830
- OSTI ID:
- 6211306
- Report Number(s):
- PNL-6829; ON: DE89008095
- Resource Relation:
- Other Information: Paper copy only, copy does not permit microfiche production
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ISOPRENE
TOXICITY
RATS
MORTALITY
COMPARATIVE EVALUATIONS
DOSE-RESPONSE RELATIONSHIPS
INHALATION
LIFE SPAN
LITTER SIZE
MICE
PRENATAL EXPOSURE
PROGRESS REPORT
SEX DEPENDENCE
TERATOGENESIS
TIME DEPENDENCE
ANIMALS
DIENES
DOCUMENT TYPES
HYDROCARBONS
INTAKE
MAMMALS
ORGANIC COMPOUNDS
POLYENES
RODENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology