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Title: Dose-response relationship of neutrons and. gamma. rays to leukemia incidence among atomic bomb survivors in Hiroshima and Nagasaki by type of leukemia, 1950--1971

Abstract

The incidence of leukemia during 1950 to 1971 in a fixed mortality sample of atomic bomb survivors in Hiroshima and Nagasaki was analyzed as a function of neutron and ..gamma.. kerma and marrow doses. Two dose-response models were tested for acute leukemia, chronic granulocytic leukemia, and all types of leukemia, respectively. Each model postulates that the leukemia incidence depends upon the sum of separate risks imposed by ..gamma.. and neutron doses. In Model I the risk from both types of radiation is assumed to be directly proportional to the respective doses, while Model II assumes that whereas the risk from neutrons is directly proportional to the dose, the risk from ..gamma.. rays is proportional to dose-squared. The analysis demonstrated that the dose-response of the two types of leukemia differed by type of radiation. The data suggested that the response of acute leukemia was best explained by Model II, while the response of chronic granulocytic leukemia depended almost linearly upon neutron dose alone, because the regression coefficients associated with ..gamma.. radiation for both Models I and II were not significant. The relative biological effectiveness (RBE) of neutrons in relation to ..gamma.. rays for incidence of acute leukemia was estimated to bemore » approximately 30/(Dn)/sup 1/2/ (95% confidence limits; 17/(Dn)/sup 1/2/ approx. 54/(Dn)/sup 1/2/) for kerma and 32/(Dn)/sup 1/2/ (95% confidence limits; 18/(Dn)/sup 1/2/ approx. 58/(Dn)/sup 1/2/) for marrow dose (Dn = neutron dose). If acute and chronic granulocytic leukemias are considered together as all types of leukemia, Model II appears to fit the data slightly better than Model I, but neither model is statistically rejected by the data.« less

Authors:
; ;
Publication Date:
Research Org.:
Radiation Effects Research Foundation, Hiroshima, Japanan
OSTI Identifier:
6210152
Resource Type:
Journal Article
Journal Name:
Radiat. Res.; (United States)
Additional Journal Information:
Journal Volume: 77:2
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; A-BOMB SURVIVORS; DELAYED RADIATION EFFECTS; BONE MARROW; RADIATION DOSES; DOSE-RESPONSE RELATIONSHIPS; MATHEMATICAL MODELS; GAMMA RADIATION; LEUKEMOGENESIS; LEUKEMIA; RADIOINDUCTION; NEUTRONS; RBE; COMPARATIVE EVALUATIONS; EXPERIMENTAL DATA; GRAPHS; HIROSHIMA; ISOLATED VALUES; NAGASAKI; NUCLEAR EXPLOSIONS; THEORETICAL DATA; ASIA; BARYONS; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BODY; CARCINOGENESIS; DATA; DATA FORMS; DISEASES; DOSES; ELECTROMAGNETIC RADIATION; ELEMENTARY PARTICLES; EXPLOSIONS; FERMIONS; HADRONS; HEMATOPOIETIC SYSTEM; HEMIC DISEASES; INFORMATION; IONIZING RADIATIONS; JAPAN; NEOPLASMS; NUCLEONS; NUMERICAL DATA; ORGANS; PATHOGENESIS; RADIATION EFFECTS; RADIATIONS; TISSUES; 560151* - Radiation Effects on Animals- Man

Citation Formats

Ishimaru, T., Otake, M., and Ichimaru, M. Dose-response relationship of neutrons and. gamma. rays to leukemia incidence among atomic bomb survivors in Hiroshima and Nagasaki by type of leukemia, 1950--1971. United States: N. p., 1979. Web. doi:10.2307/3575148.
Ishimaru, T., Otake, M., & Ichimaru, M. Dose-response relationship of neutrons and. gamma. rays to leukemia incidence among atomic bomb survivors in Hiroshima and Nagasaki by type of leukemia, 1950--1971. United States. doi:10.2307/3575148.
Ishimaru, T., Otake, M., and Ichimaru, M. Thu . "Dose-response relationship of neutrons and. gamma. rays to leukemia incidence among atomic bomb survivors in Hiroshima and Nagasaki by type of leukemia, 1950--1971". United States. doi:10.2307/3575148.
@article{osti_6210152,
title = {Dose-response relationship of neutrons and. gamma. rays to leukemia incidence among atomic bomb survivors in Hiroshima and Nagasaki by type of leukemia, 1950--1971},
author = {Ishimaru, T. and Otake, M. and Ichimaru, M.},
abstractNote = {The incidence of leukemia during 1950 to 1971 in a fixed mortality sample of atomic bomb survivors in Hiroshima and Nagasaki was analyzed as a function of neutron and ..gamma.. kerma and marrow doses. Two dose-response models were tested for acute leukemia, chronic granulocytic leukemia, and all types of leukemia, respectively. Each model postulates that the leukemia incidence depends upon the sum of separate risks imposed by ..gamma.. and neutron doses. In Model I the risk from both types of radiation is assumed to be directly proportional to the respective doses, while Model II assumes that whereas the risk from neutrons is directly proportional to the dose, the risk from ..gamma.. rays is proportional to dose-squared. The analysis demonstrated that the dose-response of the two types of leukemia differed by type of radiation. The data suggested that the response of acute leukemia was best explained by Model II, while the response of chronic granulocytic leukemia depended almost linearly upon neutron dose alone, because the regression coefficients associated with ..gamma.. radiation for both Models I and II were not significant. The relative biological effectiveness (RBE) of neutrons in relation to ..gamma.. rays for incidence of acute leukemia was estimated to be approximately 30/(Dn)/sup 1/2/ (95% confidence limits; 17/(Dn)/sup 1/2/ approx. 54/(Dn)/sup 1/2/) for kerma and 32/(Dn)/sup 1/2/ (95% confidence limits; 18/(Dn)/sup 1/2/ approx. 58/(Dn)/sup 1/2/) for marrow dose (Dn = neutron dose). If acute and chronic granulocytic leukemias are considered together as all types of leukemia, Model II appears to fit the data slightly better than Model I, but neither model is statistically rejected by the data.},
doi = {10.2307/3575148},
journal = {Radiat. Res.; (United States)},
number = ,
volume = 77:2,
place = {United States},
year = {1979},
month = {2}
}