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Title: Clinical comparison of /sup 99m/Tc--diethyl-iminodiacetic acid, /sup 99m/Tc--pyridoxylideneglutamate, and /sup 131/I-rose bengal in liver transplant patients

Abstract

The relative merits of three radiopharmaceuticals for evaluating liver transplant patients were determined in paired studies. In 86% of studies both /sup 131/I--RB and /sup 99m/Tc--PG gave similar information for differentiation of hepatocellular disease and biliary tract obstruction. /sup 99m/Tc--PG probably demonstrates the biliary tract and small intestine better early after injection (8%); /sup 131/I-RB is probably better in showing the colon at 24 hs when intestinal activity is not seen by 1 h (6%). /sup 99m/Tc--diethyl--IDA is superior in all respects when compared to /sup 99m/Tc--PG. The blood retention method (20 min./5 min.) showed that none of the radiopharmaceuticals was a reliable indicator of hepatocyte function when compared to total serum bilirubin.

Authors:
; ; ;
Publication Date:
Research Org.:
Univ. of Colorado Medical Center, Denver
OSTI Identifier:
6204676
Resource Type:
Journal Article
Journal Name:
Radiology; (United States)
Additional Journal Information:
Journal Volume: 130:2
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 59 BASIC BIOLOGICAL SCIENCES; ACETIC ACID ESTERS; RADIOPHARMACEUTICALS; BILIARY TRACT; DYNAMIC FUNCTION STUDIES; SCINTISCANNING; IMIDES; IODINE 131; LIVER; PYRIDOXYLIDENEGLUTAMATE; COMPARATIVE EVALUATIONS; ROSE BENGAL; SMALL INTESTINE; TECHNETIUM 99; TRANSPLANTS; INTRAVENOUS INJECTION; ISOMERIC NUCLEI; LABELLED COMPOUNDS; PATIENTS; AMINO ACIDS; AZINES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CARBOXYLIC ACID ESTERS; CARBOXYLIC ACIDS; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DIGESTIVE SYSTEM; DRUGS; DYES; ESTERS; GASTROINTESTINAL TRACT; GLANDS; GLUTAMIC ACID; HETEROCYCLIC COMPOUNDS; HOURS LIVING RADIOISOTOPES; HYDROXY ACIDS; INDICATORS; INJECTION; INTAKE; INTERMEDIATE MASS NUCLEI; INTESTINES; IODINE ISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; NUCLEI; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC CHLORINE COMPOUNDS; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC IODINE COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PYRIDINES; RADIOACTIVE MATERIALS; RADIOISOTOPE SCANNING; RADIOISOTOPES; REAGENTS; TECHNETIUM ISOTOPES; YEARS LIVING RADIOISOTOPES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics; 551001 - Physiological Systems- Tracer Techniques; 550901 - Pathology- Tracer Techniques

Citation Formats

Klingensmith, W.C., Fritzberg, A.R., Koep, L.J., and Ronai, P.M. Clinical comparison of /sup 99m/Tc--diethyl-iminodiacetic acid, /sup 99m/Tc--pyridoxylideneglutamate, and /sup 131/I-rose bengal in liver transplant patients. United States: N. p., 1979. Web.
Klingensmith, W.C., Fritzberg, A.R., Koep, L.J., & Ronai, P.M. Clinical comparison of /sup 99m/Tc--diethyl-iminodiacetic acid, /sup 99m/Tc--pyridoxylideneglutamate, and /sup 131/I-rose bengal in liver transplant patients. United States.
Klingensmith, W.C., Fritzberg, A.R., Koep, L.J., and Ronai, P.M. Thu . "Clinical comparison of /sup 99m/Tc--diethyl-iminodiacetic acid, /sup 99m/Tc--pyridoxylideneglutamate, and /sup 131/I-rose bengal in liver transplant patients". United States.
@article{osti_6204676,
title = {Clinical comparison of /sup 99m/Tc--diethyl-iminodiacetic acid, /sup 99m/Tc--pyridoxylideneglutamate, and /sup 131/I-rose bengal in liver transplant patients},
author = {Klingensmith, W.C. and Fritzberg, A.R. and Koep, L.J. and Ronai, P.M.},
abstractNote = {The relative merits of three radiopharmaceuticals for evaluating liver transplant patients were determined in paired studies. In 86% of studies both /sup 131/I--RB and /sup 99m/Tc--PG gave similar information for differentiation of hepatocellular disease and biliary tract obstruction. /sup 99m/Tc--PG probably demonstrates the biliary tract and small intestine better early after injection (8%); /sup 131/I-RB is probably better in showing the colon at 24 hs when intestinal activity is not seen by 1 h (6%). /sup 99m/Tc--diethyl--IDA is superior in all respects when compared to /sup 99m/Tc--PG. The blood retention method (20 min./5 min.) showed that none of the radiopharmaceuticals was a reliable indicator of hepatocyte function when compared to total serum bilirubin.},
doi = {},
journal = {Radiology; (United States)},
number = ,
volume = 130:2,
place = {United States},
year = {1979},
month = {2}
}