Jumping translocation in a newborn boy with dup(4q) and severe hydrops fetalis
Journal Article
·
· American Journal of Medical Genetics
- University Hospital Gent (Belgium)
We report on the unusual cytogenetic findings in a newborn boy with severe hydrops fetalis. He has a mosaic for 2 unbalanced chromosome rearrangements: a der(18)t(4;18)(q31;q23) and a der(18)t(4;18)(q31;p11). As a result, this patient had a duplication of 4q31-qter in cells, and was possibly monosomic for the distal ends of 18p and 18q, respectively in the 2 cell lines. Sine in both rearrangements the same chromosome 4 segment was translocated to 2 different chromosome regions, we consider the present finding as a peculiar type of jumping translocation. 32 refs., 3 figs., 1 tab.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 62013
- Journal Information:
- American Journal of Medical Genetics, Vol. 52, Issue 2; Other Information: PBD: 15 Aug 1994
- Country of Publication:
- United States
- Language:
- English
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