skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Carbon monoxide and lethal arrhythmias. Research report, Jul 85-Jan 89

Abstract

The effect of acute exposure to carbon monoxide on ventricular arrhythmias was studied in dogs with a healed anterior myocardial infarction. The combination of mild exercise and acute myocardial ischemia induces ventricular fibrillation in 60 percent of the animals. Dogs that develop ventricular fibrillation are considered at high risk for sudden death and are defined as susceptible; dogs that survive the test without fatal arrhythmia are considered at low risk and are defined as 'resistant.' The effects of carboxyhemoglobin levels ranging from 5 to 15 percent were tested in resistant and susceptible dogs. A trend toward higher heart rates was observed at rest and during exercise in both resistant and susceptible dogs at all levels of carboxyhemoglobin, although significant differences were observed only with 15 percent carboxyhemoglobin. In resistant animals, in which acute myocardial ischemia is typically associated with bradycardia even under the control condition, the reflex response occurred earlier and was augmented after exposure to carbon monoxide. In both resistant and susceptible dogs, carbon monoxide exposure induced a worsening of ventricular arrhythmias in a minority of cases. The worsening was not reproducible in subsequent trials. These data indicate that acute exposure to carbon monoxide is seldom arrhythmogenic in dogsmore » that have survived myocardial infarction. Nevertheless, the observation that carbon monoxide exposure increases heart rate at rest and during moderate exercise may have clinical implications relevant to patients with coronary artery disease.« less

Authors:
; ; ;
Publication Date:
Research Org.:
Oklahoma Univ., Oklahoma City, OK (United States). Health Sciences Center
OSTI Identifier:
6194646
Alternate Identifier(s):
OSTI ID: 6194646
Report Number(s):
PB-91-243212/XAB
Resource Type:
Technical Report
Resource Relation:
Other Information: Sponsored by Health Effects Inst., Cambridge, MA
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CARBON MONOXIDE; TOXICITY; CARDIOVASCULAR DISEASES; PATHOGENESIS; ACUTE EXPOSURE; AIR POLLUTION; CARBOXYHEMOGLOBIN; DOGS; EXERCISE; MORTALITY; MYOCARDIAL INFARCTION; ANIMALS; CARBON COMPOUNDS; CARBON OXIDES; CHALCOGENIDES; DISEASES; MAMMALS; OXIDES; OXYGEN COMPOUNDS; POLLUTION; VERTEBRATES 560300* -- Chemicals Metabolism & Toxicology

Citation Formats

Farber, J.P., Schwartz, P.J., Vanoli, E., and Stramba-Badiale, M. Carbon monoxide and lethal arrhythmias. Research report, Jul 85-Jan 89. United States: N. p., 1990. Web.
Farber, J.P., Schwartz, P.J., Vanoli, E., & Stramba-Badiale, M. Carbon monoxide and lethal arrhythmias. Research report, Jul 85-Jan 89. United States.
Farber, J.P., Schwartz, P.J., Vanoli, E., and Stramba-Badiale, M. Mon . "Carbon monoxide and lethal arrhythmias. Research report, Jul 85-Jan 89". United States.
@article{osti_6194646,
title = {Carbon monoxide and lethal arrhythmias. Research report, Jul 85-Jan 89},
author = {Farber, J.P. and Schwartz, P.J. and Vanoli, E. and Stramba-Badiale, M.},
abstractNote = {The effect of acute exposure to carbon monoxide on ventricular arrhythmias was studied in dogs with a healed anterior myocardial infarction. The combination of mild exercise and acute myocardial ischemia induces ventricular fibrillation in 60 percent of the animals. Dogs that develop ventricular fibrillation are considered at high risk for sudden death and are defined as susceptible; dogs that survive the test without fatal arrhythmia are considered at low risk and are defined as 'resistant.' The effects of carboxyhemoglobin levels ranging from 5 to 15 percent were tested in resistant and susceptible dogs. A trend toward higher heart rates was observed at rest and during exercise in both resistant and susceptible dogs at all levels of carboxyhemoglobin, although significant differences were observed only with 15 percent carboxyhemoglobin. In resistant animals, in which acute myocardial ischemia is typically associated with bradycardia even under the control condition, the reflex response occurred earlier and was augmented after exposure to carbon monoxide. In both resistant and susceptible dogs, carbon monoxide exposure induced a worsening of ventricular arrhythmias in a minority of cases. The worsening was not reproducible in subsequent trials. These data indicate that acute exposure to carbon monoxide is seldom arrhythmogenic in dogs that have survived myocardial infarction. Nevertheless, the observation that carbon monoxide exposure increases heart rate at rest and during moderate exercise may have clinical implications relevant to patients with coronary artery disease.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1990},
month = {1}
}

Technical Report:
Other availability
Please see Document Availability for additional information on obtaining the full-text document. Library patrons may search WorldCat to identify libraries that may hold this item. Keep in mind that many technical reports are not cataloged in WorldCat.

Save / Share: