Experience with NQA-1 quality assurance standards applied to in vitro bioassay
On June 1, 1990, the large (about 4000 samples per year) excreta bioassay program at the Hanford Site ceased abruptly when the contract with the bioassay laboratory was terminated. An intense, high-priority effort was begun to replace the services on an interim basis until a new contract could be procured. Despite the urgency to get the excreta bioassay program going again, the Hanford Internal Dosimetry Program was constrained to use only labs that could meet stringent quality assurance (QA) requirements, even during the interim period. The QA requirements were based on NQA-1 with selected additions from the Environmental Protection Agency's QAMS 005/80 (EPA 1983) and the American Society for Testing and Materials' C 1009-83 (ASTM 1984). This constraint was driven both by legal reasons and by the Hanford Site contractors and workers not wanting the quality of the data to be sacrificed. Finding labs that could (1) handle the large throughput, (2) meet the technical requirements, and (3) pass the QA audit proved more difficult than first anticipated. This presentation focuses on the QA requirements that the labs had to meet and how those very broad requirements were applied specifically to excreta bioassay. 5 refs.
- Research Organization:
- Pacific Northwest Lab., Richland, WA (United States)
- Sponsoring Organization:
- USDOE; USDOE, Washington, DC (United States)
- DOE Contract Number:
- AC06-76RL01830
- OSTI ID:
- 6194357
- Report Number(s):
- PNL-SA-19395; CONF-911004-4; ON: DE92002679; TRN: 91-032863
- Resource Relation:
- Conference: 3. conference on radiation protection and dosimetry, Orlando, FL (United States), 21-24 Oct 1991
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
61 RADIATION PROTECTION AND DOSIMETRY
BIOLOGICAL WASTES
BIOASSAY
QUALITY ASSURANCE
SPECIFICATIONS
AUDITS
COMPUTER CODES
CONTRACTORS
DATA ANALYSIS
DATA COMPILATION
DOCUMENTATION
HANFORD RESERVATION
IN VITRO
MEASURING METHODS
MEDICAL RECORDS
RECORDS MANAGEMENT
BIOLOGICAL MATERIALS
DATA
INFORMATION
MANAGEMENT
MATERIALS
NATIONAL ORGANIZATIONS
US DOE
US ERDA
US ORGANIZATIONS
WASTES
570000* - Health & Safety
560190 - Radiation Protection Standards- (1992-)