Design of steady-state positron emission tomography protocols for neurobehavioral studies: CO/sup 15/O and /sup 19/Ne
Although the (/sup 18/F)-2-fluoro-2-deoxyglucose positron emission tomographic technique for measuring regional glucose metabolic rate has been successfully employed for neurobehavioral studies, the long (greater than 30 min) equilibration time required may complicate the interpretation of experimental results. Positron emission tomography neurobehavioral protocols employing the continuous inhalation of CO/sup 15/O and /sup 19/Ne were developed for measuring regional cerebral blood flow during multiple control and stimulation periods. Timing, lung absorbed dose, statistical accuracy, and resolution were considered. Studies with /sup 19/Ne require shorter equilibration and stimulation times than do CO/sup 15/O studies but entail higher absorbed doses and yield poorer imaging statistics.
- Research Organization:
- Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, NY
- OSTI ID:
- 6191369
- Journal Information:
- J. Comput. Assist. Tomogr.; (United States), Vol. 7:1
- Country of Publication:
- United States
- Language:
- English
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RADIATION DOSES
ALDEHYDES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
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BRAIN
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CENTRAL NERVOUS SYSTEM
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EMISSION COMPUTED TOMOGRAPHY
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HOURS LIVING RADIOISOTOPES
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LIGHT NUCLEI
MINUTES LIVING RADIOISOTOPES
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NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
OXYGEN ISOTOPES
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SECONDS LIVING RADIOISOTOPES
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550601* - Medicine- Unsealed Radionuclides in Diagnostics