Linkage analysis of chromosome 17q markers and breast-ovarian cancer in Icelandic families, and possible relationship to prostatic cancer
- University Hospital of Iceland, Reykjavik (Iceland)
Seven families, selected for breast cancer segregation, have been analyzed for chromosome 17q12-q23 linkage to breast and ovarian cancer. In two of them, linkage is seen with most markers tested, increasing toward the most proximal region, but without informative recombinations above NM23. In the remaining families, no linkage is observed. Families with 17q linkage are not easily distinguished by clinical characteristics such as early onset (mean age at diagnosis [le]45 years) or organs involved. In fact, the family with the highest lod scores ([ge]2.3) belongs to the [open quotes]later onset[close quotes] (>45 years) category of families. Interestingly, prostatic cancer is the most frequent malignancy, after breast cancer, in the families that were studied (13 cases total, all metastasizing) and is especially prevalent in males presumed to carry the trait. Of 16 paternal carriers, 7 (44%) had developed prostatic cancer. Haplotype analysis in families with 17q linkage reveals two further prostatic cases as potential carriers. The authors propose that breast cancer genes may predispose to prostatic cancer in male carriers. 12 refs., 2 figs., 2 tabs.
- OSTI ID:
- 6180295
- Journal Information:
- American Journal of Human Genetics; (United States), Vol. 52:4; ISSN 0002-9297
- Country of Publication:
- United States
- Language:
- English
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HUMAN CHROMOSOME 17
GENETIC MAPPING
MAMMARY GLANDS
NEOPLASMS
PROSTATE
BIOLOGICAL MARKERS
ICELAND
OVARIES
BODY
CHROMOSOMES
DEVELOPING COUNTRIES
DISEASES
EUROPE
FEMALE GENITALS
GLANDS
GONADS
HUMAN CHROMOSOMES
ISLANDS
MALE GENITALS
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WESTERN EUROPE
550400* - Genetics