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Title: Method of analysis to derive cell survival from observation of tissue damage following fractionated irradiation. [Mouse foot skin reaction data are used to derive epithelial stem cell survival parameters]

Abstract

A general analysis technique is introduced for extracting in vivo cell survival equation parameters from observation of tissue damage following fractionated doses of radiation. This technique has been applied to a new set of mouse foot skin-reaction data and it has been possible to demonstrate that the parameters for an assumed survival equation can be determined independently of the arbitrary definition of the average skin reaction. Since all data points are used, no graphical data interpolation is required and the use of an arbitrary level of damage for isoeffect comparison is not necessary.

Authors:
 [1]; ; ;
  1. (Univ. of British Columbia, Vancouver, Canada)
Publication Date:
OSTI Identifier:
6179673
Resource Type:
Journal Article
Journal Name:
Radiat. Res.; (United States)
Additional Journal Information:
Journal Volume: 77:3
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; EPITHELIUM; STEM CELLS; SKIN; BIOLOGICAL RADIATION EFFECTS; SURVIVAL TIME; DATA ANALYSIS; MATHEMATICAL MODELS; FEET; FRACTIONATED IRRADIATION; ISOLATED VALUES; LOCAL IRRADIATION; MICE; THEORETICAL DATA; X RADIATION; ANIMAL CELLS; ANIMALS; BIOLOGICAL EFFECTS; BODY; BODY AREAS; DATA; DATA FORMS; ELECTROMAGNETIC RADIATION; INFORMATION; IONIZING RADIATIONS; IRRADIATION; LEGS; LIMBS; MAMMALS; NUMERICAL DATA; ORGANS; RADIATION EFFECTS; RADIATIONS; RODENTS; SOMATIC CELLS; TISSUES; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals

Citation Formats

Lam, G.K.Y., Henkelman, R.M., Douglas, B.G., and Eaves, C.J. Method of analysis to derive cell survival from observation of tissue damage following fractionated irradiation. [Mouse foot skin reaction data are used to derive epithelial stem cell survival parameters]. United States: N. p., 1979. Web. doi:10.2307/3575156.
Lam, G.K.Y., Henkelman, R.M., Douglas, B.G., & Eaves, C.J. Method of analysis to derive cell survival from observation of tissue damage following fractionated irradiation. [Mouse foot skin reaction data are used to derive epithelial stem cell survival parameters]. United States. doi:10.2307/3575156.
Lam, G.K.Y., Henkelman, R.M., Douglas, B.G., and Eaves, C.J. Thu . "Method of analysis to derive cell survival from observation of tissue damage following fractionated irradiation. [Mouse foot skin reaction data are used to derive epithelial stem cell survival parameters]". United States. doi:10.2307/3575156.
@article{osti_6179673,
title = {Method of analysis to derive cell survival from observation of tissue damage following fractionated irradiation. [Mouse foot skin reaction data are used to derive epithelial stem cell survival parameters]},
author = {Lam, G.K.Y. and Henkelman, R.M. and Douglas, B.G. and Eaves, C.J.},
abstractNote = {A general analysis technique is introduced for extracting in vivo cell survival equation parameters from observation of tissue damage following fractionated doses of radiation. This technique has been applied to a new set of mouse foot skin-reaction data and it has been possible to demonstrate that the parameters for an assumed survival equation can be determined independently of the arbitrary definition of the average skin reaction. Since all data points are used, no graphical data interpolation is required and the use of an arbitrary level of damage for isoeffect comparison is not necessary.},
doi = {10.2307/3575156},
journal = {Radiat. Res.; (United States)},
number = ,
volume = 77:3,
place = {United States},
year = {1979},
month = {3}
}