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Title: Transplantation of bone marrow in outbred dogs without graft-versus-host disease using total lymphoid irradiation

Abstract

The experimental findings reported here confirm and extend our earlier studies which show that preparation of adult mice and rats with TLI allows allogeneic marrow engraftment without GVHD. The immunological mechanisms responsible for the absence of GVHD is unclear. Unlike the presently used recipient treatment regimens, TLI allows for the use of unmatched marrow and obviates the use of post-transplant immunosuppressive therapy. Achievement of marrow engraftment without GVHD in large outbred animals indicates that this technique merits further investigation as a potential tool in marrow transplantation in humans.

Authors:
; ; ; ; ; ;
Publication Date:
Research Org.:
Stanford Univ. School of Medicine, CA
OSTI Identifier:
6179616
Resource Type:
Journal Article
Journal Name:
Transplantation; (United States)
Additional Journal Information:
Journal Volume: 27:2
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; BONE MARROW; TRANSPLANTS; BONE MARROW CELLS; KARYOTYPE; GRAFT-HOST REACTION; LYMPHATIC SYSTEM; BIOLOGICAL RADIATION EFFECTS; IMMUNE REACTIONS; DOGS; EXPERIMENTAL DATA; GRAPHS; ISOLATED VALUES; LYMPHOCYTES; RADIATIONS; ANIMAL CELLS; ANIMALS; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY; BODY FLUIDS; CONNECTIVE TISSUE CELLS; DATA; DATA FORMS; HEMATOPOIETIC SYSTEM; INFORMATION; LEUKOCYTES; MAMMALS; NUMERICAL DATA; ORGANS; RADIATION EFFECTS; SOMATIC CELLS; TISSUES; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals

Citation Formats

Slavin, S., Gottlieb, M., Strober, S., Bieber, C., Hoppe, R., Kaplan, H.S., and Grumet, F.C. Transplantation of bone marrow in outbred dogs without graft-versus-host disease using total lymphoid irradiation. United States: N. p., 1979. Web.
Slavin, S., Gottlieb, M., Strober, S., Bieber, C., Hoppe, R., Kaplan, H.S., & Grumet, F.C. Transplantation of bone marrow in outbred dogs without graft-versus-host disease using total lymphoid irradiation. United States.
Slavin, S., Gottlieb, M., Strober, S., Bieber, C., Hoppe, R., Kaplan, H.S., and Grumet, F.C. Thu . "Transplantation of bone marrow in outbred dogs without graft-versus-host disease using total lymphoid irradiation". United States.
@article{osti_6179616,
title = {Transplantation of bone marrow in outbred dogs without graft-versus-host disease using total lymphoid irradiation},
author = {Slavin, S. and Gottlieb, M. and Strober, S. and Bieber, C. and Hoppe, R. and Kaplan, H.S. and Grumet, F.C.},
abstractNote = {The experimental findings reported here confirm and extend our earlier studies which show that preparation of adult mice and rats with TLI allows allogeneic marrow engraftment without GVHD. The immunological mechanisms responsible for the absence of GVHD is unclear. Unlike the presently used recipient treatment regimens, TLI allows for the use of unmatched marrow and obviates the use of post-transplant immunosuppressive therapy. Achievement of marrow engraftment without GVHD in large outbred animals indicates that this technique merits further investigation as a potential tool in marrow transplantation in humans.},
doi = {},
journal = {Transplantation; (United States)},
number = ,
volume = 27:2,
place = {United States},
year = {1979},
month = {2}
}