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Title: Determination of trace endocrine active phenolic compounds by GC/MS

Abstract

4-Nonylphenol ethoxylates (NPEOs) and 4-octylphenol ethoxylates (OPEOs) are widely used as nonionic surfactants, Due to the potential estrogenic properties of these compounds and their biodegradation products, there is increasing concern about their presence in ground and drinking water. To assess their prevalence in drinking and ground water, a simple, highly sensitive and accurate analytical method for determination of trace amounts of 4-nonylphenol, 4-nonylphenol monoethoxylate (NP1EO), 4-nonylphenol diethoxylate (NP2EO), 4-nonylphenol monoethoxycarboxylate (NP1EC), 4-octylphenol, 4-octylphenol monoethoxylate (OP1EO), 4-octylphenol diethoxylate (OP2EO), and other 15 phenolic compounds has been developed and validated. One liter of drinking water sample was extracted and concentrated into dichloromethane. The analytes in the extracts were converted to their trimethylsilyl derivatives by reacting with N,O-bis(trimethylsilyl) trifluoroacetamine (BSTFA) and 10 % trimethylchlorosilane (TMCS) at 90{degrees}C. The derivatized extracts were then directly analyzed by gas chromatography-mass spectrometry operating in a selected-ion monitoring mode (GUMS-SIM). Method detection limits (MDLs) were 0.01 to 0.02 {mu}g/L for 4-nonylphenol, NP1EO, 2PNEO; 0.064 {mu}g/L for NP1EC; 0.005 to 0.02 {mu}g/L for 4-octylphenol, OP1EO, OP2EO; and 0.001 to 0.003 {mu}g/L, for other 15 phenolic compounds.

Authors:
;  [1]
  1. Southwest Research Institute, San Antonio, TX (United States)
Publication Date:
OSTI Identifier:
617787
Report Number(s):
CONF-9704195-
TRN: 98:002116-0038
Resource Type:
Conference
Resource Relation:
Conference: Specialty conference on measurement of toxic and related air pollutants, Research Triangle Park, NC (United States), 29 Apr - 1 May 1997; Other Information: PBD: 1997; Related Information: Is Part Of Measurement of toxic and related air pollutants. Volume 1 and 2; PB: 1004 p.
Country of Publication:
United States
Language:
English
Subject:
54 ENVIRONMENTAL SCIENCES; 56 BIOLOGY AND MEDICINE, APPLIED STUDIES; GAS CHROMATOGRAPHY; GROUND WATER; MONITORING; POLLUTANTS; SURFACTANTS; TRACE AMOUNTS; MASS SPECTRA; PHENOLS; DRINKING WATER; HEALTH HAZARDS

Citation Formats

Sun, Gang, and Geno, P W. Determination of trace endocrine active phenolic compounds by GC/MS. United States: N. p., 1997. Web.
Sun, Gang, & Geno, P W. Determination of trace endocrine active phenolic compounds by GC/MS. United States.
Sun, Gang, and Geno, P W. Wed . "Determination of trace endocrine active phenolic compounds by GC/MS". United States.
@article{osti_617787,
title = {Determination of trace endocrine active phenolic compounds by GC/MS},
author = {Sun, Gang and Geno, P W},
abstractNote = {4-Nonylphenol ethoxylates (NPEOs) and 4-octylphenol ethoxylates (OPEOs) are widely used as nonionic surfactants, Due to the potential estrogenic properties of these compounds and their biodegradation products, there is increasing concern about their presence in ground and drinking water. To assess their prevalence in drinking and ground water, a simple, highly sensitive and accurate analytical method for determination of trace amounts of 4-nonylphenol, 4-nonylphenol monoethoxylate (NP1EO), 4-nonylphenol diethoxylate (NP2EO), 4-nonylphenol monoethoxycarboxylate (NP1EC), 4-octylphenol, 4-octylphenol monoethoxylate (OP1EO), 4-octylphenol diethoxylate (OP2EO), and other 15 phenolic compounds has been developed and validated. One liter of drinking water sample was extracted and concentrated into dichloromethane. The analytes in the extracts were converted to their trimethylsilyl derivatives by reacting with N,O-bis(trimethylsilyl) trifluoroacetamine (BSTFA) and 10 % trimethylchlorosilane (TMCS) at 90{degrees}C. The derivatized extracts were then directly analyzed by gas chromatography-mass spectrometry operating in a selected-ion monitoring mode (GUMS-SIM). Method detection limits (MDLs) were 0.01 to 0.02 {mu}g/L for 4-nonylphenol, NP1EO, 2PNEO; 0.064 {mu}g/L for NP1EC; 0.005 to 0.02 {mu}g/L for 4-octylphenol, OP1EO, OP2EO; and 0.001 to 0.003 {mu}g/L, for other 15 phenolic compounds.},
doi = {},
url = {https://www.osti.gov/biblio/617787}, journal = {},
number = ,
volume = ,
place = {United States},
year = {1997},
month = {12}
}

Conference:
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