Mathematical model for prediction of copy number and protein production in E. coli

Conference · Tue Jan 01 00:00:00 EST 1985

OSTI ID:6177729

Ataai, M M; Shuler, M L

The design of bioreactors for genetically modified bacterial cultures would benefit from predictive models. Of particular importance is the interaction of the abiotic environment, cell physiology, and control of plasmid copy number. The authors already have an excellent base model for Escherichia coli, the organism most extensively used in genetic manipulation. We have also recently developed a molecular mechanism model for control of replication of ColE1 type plasmids. The inclusion of the plasmid model into the E. coli cell-model allows the explicit predictions of the interaction of cell physiology and plasmid encoded functions.

• Research Organization: Cornell Univ., Ithaca, NY 14853
• OSTI ID: 6177729
• Report Number(s): CONF-851123-
• Resource Relation: Conference: American Institute of Chemical Engineers annual winter meeting, Chicago, IL, USA, 10 Nov 1985; Other Information: Technical Paper 41D
• Country of Publication: United States
• Language: English

Related Subjects

09 BIOMASS FUELS
59 BASIC BIOLOGICAL SCIENCES
BIOREACTORS
CELL CULTURES
MATHEMATICAL MODELS
ESCHERICHIA COLI
CELL PROLIFERATION
PLASMIDS
BIOCHEMISTRY
DESIGN
GENE MUTATIONS
GENE RECOMBINATION
GENES
INTERACTIONS
MOLECULAR STRUCTURE
PROTEINS
RNA
STABILITY
BACTERIA
CELL CONSTITUENTS
CHEMISTRY
MICROORGANISMS
MUTATIONS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
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