Biphasic effects of ethanol and sodium oleate on synaptic transport of aspartic acid

Conference · Fri May 01 00:00:00 EDT 1987 · Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)

OSTI ID:6175475

Foley, T; Rhoads, D E

The authors have examined the effects of ethanol and sodium oleate on the transport of aspartic acid (ASP) by nerve-ending preparations from rat cerebral cortex. Physiologically relevant ethanol concentrations of up to 100mM stimulated ASP uptake while concentrations greater than 200mM caused inhibition. A similar biphasic effect was observed with oleate stimulating ASP uptake at 0.1 to 1..mu..M and inhibiting ASP uptake at concentrations greater than 1..mu..M. Maximum stimulation was observed at 0.1..mu..M oleate and at 50mM ethanol. In contrast, when synaptosomes were prepared from rats that had been exposed for 2-3 weeks to 10% ethanol in their drinking water, higher concentrations of ethanol and oleate were required to obtain comparable stimulation of ASP uptake. These biphasic effects on ASP transport can be interpreted in terms of physicochemical alterations in the synaptic membranes, with from alcohol-exposed rats showing tolerance to these fluidizing effects.

• Research Organization: Univ. of Rhode Island, Kingston
• OSTI ID: 6175475
• Report Number(s): CONF-870644-
• Journal Information: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States), Vol. 46:6; Conference: 78. annual meeting of the American Society of Biological Chemists conference, Philadelphia, PA, USA, 7 Jun 1987
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ASPARTIC ACID
MEMBRANE TRANSPORT
ETHANOL
BIOLOGICAL EFFECTS
BRAIN
CELL MEMBRANES
NERVES
OLEIC ACID
RATS
SODIUM COMPOUNDS
ALCOHOLS
ALKALI METAL COMPOUNDS
AMINO ACIDS
ANIMALS
BODY
CARBOXYLIC ACIDS
CELL CONSTITUENTS
CENTRAL NERVOUS SYSTEM
HYDROXY COMPOUNDS
MAMMALS
MEMBRANES
MONOCARBOXYLIC ACIDS
NERVOUS SYSTEM
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RODENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology