Dept. of Pharmacology and Toxicology, University of Rochester, School of Medicine and Dentistry, New York. [Effect of CdCl/sub 2/]

Levin, A A; Miller, R K

Title: Dept. of Pharmacology and Toxicology, University of Rochester, School of Medicine and Dentistry, New York. [Effect of CdCl/sub 2/]

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Abstract

Fetal death in rats was produced by subcutaneous injections of CdC12 (40 mu moles/kg) on day 18 of pregnancy. The incidence of fetal death following these maternal injections was 74.9%, with mean (+/- SD) fetal cadmium burdens of 8.6 +/- 4.4 nmoles. To separate maternal from fetal effects of cadmium, doses of CdC12 up to 60 mu moles/kg fetal weight were injected directly into fetuses on day 18 of gestation. Fetal viability was then determined on gestational day 21. Following direct fetal injection, mean fetal body burdens of cadmium were 74.6 +/- 34.8 n moles, but the incidence of fetal dealth was only 11.5%. The high incidence of fetal death following maternal exposure to CdC12 is not solely explained by the direct effects of CdC12 on the fetus. Thus, the fetal toxicity of cadmium may be the result of some extra-fetal mechanism such as maternal toxicity or the observed placental necrosis.

Authors:: Levin, A A; Miller, R K

Publication Date:: Fri Aug 01 00:00:00 EDT 1980

OSTI Identifier:: 6170436

Resource Type:: Journal Article

Journal Name:: Teratology; (United States)

Additional Journal Information:: Journal Volume: 22:1

Country of Publication:: United States

Language:: English

Subject:: 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CADMIUM; TOXICITY; FETUSES; MORTALITY; BODY BURDEN; CADMIUM CHLORIDES; NECROSIS; PLACENTA; RATS; SUBCUTANEOUS INJECTION; VIABILITY; ANIMALS; CADMIUM COMPOUNDS; CADMIUM HALIDES; CHLORIDES; CHLORINE COMPOUNDS; ELEMENTS; FETAL MEMBRANES; HALIDES; HALOGEN COMPOUNDS; INJECTION; INTAKE; MAMMALS; MEMBRANES; METALS; PATHOLOGICAL CHANGES; RODENTS; VERTEBRATES; 560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)

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                    Levin, A A, and Miller, R K. Dept. of Pharmacology and Toxicology, University of Rochester, School of Medicine and Dentistry, New York. [Effect of CdCl/sub 2/].  United States: N. p., 1980. 
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                    Levin, A A, & Miller, R K. Dept. of Pharmacology and Toxicology, University of Rochester, School of Medicine and Dentistry, New York. [Effect of CdCl/sub 2/].  United States.

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                    Levin, A A, and Miller, R K. 1980.  
        "Dept. of Pharmacology and Toxicology, University of Rochester, School of Medicine and Dentistry, New York. [Effect of CdCl/sub 2/]".  United States.

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@article{osti_6170436,

  title        = {Dept. of Pharmacology and Toxicology, University of Rochester, School of Medicine and Dentistry, New York. [Effect of CdCl/sub 2/]},

  author       = {Levin, A A and Miller, R K},

  abstractNote = {Fetal death in rats was produced by subcutaneous injections of CdC12 (40 mu moles/kg) on day 18 of pregnancy. The incidence of fetal death following these maternal injections was 74.9%, with mean (+/- SD) fetal cadmium burdens of 8.6 +/- 4.4 nmoles. To separate maternal from fetal effects of cadmium, doses of CdC12 up to 60 mu moles/kg fetal weight were injected directly into fetuses on day 18 of gestation. Fetal viability was then determined on gestational day 21. Following direct fetal injection, mean fetal body burdens of cadmium were 74.6 +/- 34.8 n moles, but the incidence of fetal dealth was only 11.5%. The high incidence of fetal death following maternal exposure to CdC12 is not solely explained by the direct effects of CdC12 on the fetus. Thus, the fetal toxicity of cadmium may be the result of some extra-fetal mechanism such as maternal toxicity or the observed placental necrosis.},

  doi          = {},

  url          = {https://www.osti.gov/biblio/6170436},
  journal      = {Teratology; (United States)},
number       = ,

  volume       = 22:1,

  place        = {United States},

  year         = {Fri Aug 01 00:00:00 EDT 1980},

  month        = {Fri Aug 01 00:00:00 EDT 1980}

}

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