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Title: Radiation decomposition of technetium-99m radiopharmaceuticals. [Glucnates, pyrophosphates, and serum albumins]

Abstract

Technetium-99m radiopharmaceuticals are shown to be subject to autoradiation-induced decomposition, which results in increasing abundance of pertechnetate in the preparation. This autodecomposition is catalyzed by the presence of oxygen, although the removal of oxygen does not prevent its occurrence. The initial appearance of pertechnetate in the radiopharmaceutical is shown to be a function of the amount of radioactivity, the quantity of stannous ion used, and the ratio of /sup 99m/Tc to total technetium in the preparation.

Authors:
; ;
Publication Date:
Research Org.:
Health Sciences Centre, Winnipeg, Manitoba
OSTI Identifier:
6168703
Resource Type:
Journal Article
Journal Name:
J. Nucl. Med.; (United States)
Additional Journal Information:
Journal Volume: 20:2
Country of Publication:
United States
Language:
English
Subject:
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY; 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; OXYGEN; RADIOSENSITIVITY EFFECTS; RADIOPHARMACEUTICALS; AUTORADIOLYSIS; TIN COMPOUNDS; ALBUMINS; GLUCONIC ACID; ISOMERIC NUCLEI; PYROPHOSPHATES; TECHNETIUM 99; TIME DEPENDENCE; AUTOLYSIS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CARBOXYLIC ACIDS; CHEMICAL RADIATION EFFECTS; CHEMICAL REACTIONS; CHEMISTRY; CRYOGENIC FLUIDS; DECOMPOSITION; DRUGS; ELEMENTS; FLUIDS; HOURS LIVING RADIOISOTOPES; HYDROXY ACIDS; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; NONMETALS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; OXYGEN COMPOUNDS; PHOSPHORUS COMPOUNDS; PROTEINS; RADIATION CHEMISTRY; RADIATION EFFECTS; RADIOACTIVE MATERIALS; RADIOISOTOPES; RADIOLYSIS; TECHNETIUM ISOTOPES; YEARS LIVING RADIOISOTOPES; 400702* - Radiochemistry & Nuclear Chemistry- Properties of Radioactive Materials; 560111 - Radiation Effects on Biochemicals- In Vitro- (-1987)

Citation Formats

Billinghurst, M.W., Rempel, S., and Westendorf, B.A. Radiation decomposition of technetium-99m radiopharmaceuticals. [Glucnates, pyrophosphates, and serum albumins]. United States: N. p., 1979. Web.
Billinghurst, M.W., Rempel, S., & Westendorf, B.A. Radiation decomposition of technetium-99m radiopharmaceuticals. [Glucnates, pyrophosphates, and serum albumins]. United States.
Billinghurst, M.W., Rempel, S., and Westendorf, B.A. Thu . "Radiation decomposition of technetium-99m radiopharmaceuticals. [Glucnates, pyrophosphates, and serum albumins]". United States.
@article{osti_6168703,
title = {Radiation decomposition of technetium-99m radiopharmaceuticals. [Glucnates, pyrophosphates, and serum albumins]},
author = {Billinghurst, M.W. and Rempel, S. and Westendorf, B.A.},
abstractNote = {Technetium-99m radiopharmaceuticals are shown to be subject to autoradiation-induced decomposition, which results in increasing abundance of pertechnetate in the preparation. This autodecomposition is catalyzed by the presence of oxygen, although the removal of oxygen does not prevent its occurrence. The initial appearance of pertechnetate in the radiopharmaceutical is shown to be a function of the amount of radioactivity, the quantity of stannous ion used, and the ratio of /sup 99m/Tc to total technetium in the preparation.},
doi = {},
journal = {J. Nucl. Med.; (United States)},
number = ,
volume = 20:2,
place = {United States},
year = {1979},
month = {2}
}