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Title: Comparison of the distribution of diagnostic and thyroablative /sup 131/I in the evaluation of differentiated thyroid cancers

Abstract

In 206 patients with differentiated thyroid cancer, the distributions of iodine-131 were compared after diagnostic (200 to 500 ..mu..Ci) and thyroblative (approx.100 mCi) doses. In the diagnostic scans, only normal thyroid tissue could be seen, whereas in one-fourth of the patients the therapeutic scans showed tumor tissue as well, usually in lymph-node metastases. In 16% of patients, the therapeutic scan was the only way to demonstrate the presence of tumor tissue, since no further uptake was achievable. In patients in whom all tumor was believed to have been removed by surgery alone, a preventive /sup 131/I ablation was used, and in 16 of these 97 patients tumor was revealed in the therapeutic scan. In ten more, tumor was found in subsequent followup scans, its functioning having been induced by destruction of postsurgical remnants of normal thyroid. Some possible explanations for the differences in scans are proposed, and the importance of therapeutic scans for correct staging of thyroid cancer is stressed.

Authors:
; ; ;
Publication Date:
Research Org.:
Research Inst. of Endocrinology, Prague, Czechoslovakia
OSTI Identifier:
6165542
Resource Type:
Journal Article
Journal Name:
J. Nucl. Med.; (United States)
Additional Journal Information:
Journal Volume: 20:2
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; BIOLOGICAL LOCALIZATION; DOSE-RESPONSE RELATIONSHIPS; IODINE 131; SCINTISCANNING; METASTASES; DIAGNOSIS; THYROID; NEOPLASMS; PATIENTS; RADIOTHERAPY; SURGERY; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DISEASES; ENDOCRINE GLANDS; GLANDS; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPES; MEDICINE; NUCLEAR MEDICINE; NUCLEI; ODD-EVEN NUCLEI; ORGANS; RADIOISOTOPE SCANNING; RADIOISOTOPES; RADIOLOGY; THERAPY; 550601* - Medicine- Unsealed Radionuclides in Diagnostics; 550604 - Medicine- Unsealed Radionuclides in Therapy- (1980-); 560171 - Radiation Effects- Nuclide Kinetics & Toxicology- Man- (-1987)

Citation Formats

Nemec, J., Roehling, S., Zamrazil, V., and Pohunkova, D. Comparison of the distribution of diagnostic and thyroablative /sup 131/I in the evaluation of differentiated thyroid cancers. United States: N. p., 1979. Web.
Nemec, J., Roehling, S., Zamrazil, V., & Pohunkova, D. Comparison of the distribution of diagnostic and thyroablative /sup 131/I in the evaluation of differentiated thyroid cancers. United States.
Nemec, J., Roehling, S., Zamrazil, V., and Pohunkova, D. Thu . "Comparison of the distribution of diagnostic and thyroablative /sup 131/I in the evaluation of differentiated thyroid cancers". United States.
@article{osti_6165542,
title = {Comparison of the distribution of diagnostic and thyroablative /sup 131/I in the evaluation of differentiated thyroid cancers},
author = {Nemec, J. and Roehling, S. and Zamrazil, V. and Pohunkova, D.},
abstractNote = {In 206 patients with differentiated thyroid cancer, the distributions of iodine-131 were compared after diagnostic (200 to 500 ..mu..Ci) and thyroblative (approx.100 mCi) doses. In the diagnostic scans, only normal thyroid tissue could be seen, whereas in one-fourth of the patients the therapeutic scans showed tumor tissue as well, usually in lymph-node metastases. In 16% of patients, the therapeutic scan was the only way to demonstrate the presence of tumor tissue, since no further uptake was achievable. In patients in whom all tumor was believed to have been removed by surgery alone, a preventive /sup 131/I ablation was used, and in 16 of these 97 patients tumor was revealed in the therapeutic scan. In ten more, tumor was found in subsequent followup scans, its functioning having been induced by destruction of postsurgical remnants of normal thyroid. Some possible explanations for the differences in scans are proposed, and the importance of therapeutic scans for correct staging of thyroid cancer is stressed.},
doi = {},
journal = {J. Nucl. Med.; (United States)},
number = ,
volume = 20:2,
place = {United States},
year = {1979},
month = {2}
}