How and why of in vitro oncogenic transformation. [X-rays: /sup 60/Co]

Conference · Sat Aug 01 00:00:00 EDT 1981 · Radiat. Res.; (United States)

OSTI ID:6162437

Hall, E J; Miller, R C

The techniques devised to study oncogenic transformation in vitro, involving established cell lines as well as fresh explants from hamster embryos, represent a powerful tool to study the mechanisms involved in radiation carcinogenesis. Large numbers of cells can be irradiated and transformation incidence scored over a wide range of doses down to as low as 0.01 Gy of X rays. When data with small confidence intervals are available for doses below 1 Gy, it becomes evident that the dose-response relationship has a complex shape and is not well represented by a linear relationship between transformation incidence and dose. It has been clearly demonstrated with this in vitro system that the temporal distribution of dose, in particular its protraction over a period of time, significantly enhances transformation incidence at relatively low doses. These experiments have important implications to the development of risk estimates for radiogenic cancer in humans exposed to low doses, which involves an extrapolation from the available data which relate to high dose levels.

• Research Organization: Columbia Univ., New York, NY
• DOE Contract Number: AC02-78EV04733
• OSTI ID: 6162437
• Journal Information: Radiat. Res.; (United States), Vol. 87:2; Conference: Symposium on low dose and low dose rate effects and their significance, New Orleans, LA, USA, 1 Jun 1980
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
EMBRYONIC CELLS
ONCOGENIC TRANSFORMATIONS
FIBROBLASTS
MORPHOLOGICAL CHANGES
RADIOINDUCTION
ACUTE IRRADIATION
COBALT 60
DOSE-RESPONSE RELATIONSHIPS
FRACTIONATED IRRADIATION
GAMMA RADIATION
HAMSTERS
IN VITRO
LOW DOSE IRRADIATION
MICE
X RADIATION
ACUTE EXPOSURE
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
COBALT ISOTOPES
CONNECTIVE TISSUE CELLS
ELECTROMAGNETIC RADIATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-ODD NUCLEI
RADIATIONS
RADIOISOTOPES
RODENTS
SOMATIC CELLS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560121* - Radiation Effects on Cells- External Source- (-1987)