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Title: Normal appearance and reproducibility of liver-spleen studies with /sup 99m/Tc sulfur colloid and /sup 99m/Tc microalbumin colloid

Abstract

In order to determine the normal biodistribution and reproducibility of /sup 99m/Tc sulfur colloid and /sup 99m/Tc microalbumin colloid, each of ten normal subjects was studied twice with each of the two agents. In overexposed delayed analog images of the anterior chest, some thyroid radioactivity was demonstrated in all of 20 microalbumin colloid studies and in none of 20 sulfur colloid studies; lung radioactivity was seen in 19 of 20 (95%) sulfur colloid studies and in none of the microalbumin colloid studies (both p less than 0.001). Delayed digital images showed that the sulfur colloid gave a higher lung-to-heart ratio, a higher lung-to-liver ratio, and a lower bone marrow-to-liver ratio compared with microalbumin colloid (all p less than 0.05). In general, reproducibility was poor for both agents. We conclude that while there are some differences between these two radiocolloids, the differences do not indicate a superiority of the newer Tc-99m microalbumin colloid over the established Tc-99m sulfur colloid for liver-spleen imaging.

Authors:
; ; ;
Publication Date:
Research Org.:
University of Colorado Health Sciences Center, Denver
OSTI Identifier:
6148327
Resource Type:
Journal Article
Journal Name:
J. Nucl. Med.; (United States)
Additional Journal Information:
Journal Volume: 24:1
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 59 BASIC BIOLOGICAL SCIENCES; LIVER; BIOMEDICAL RADIOGRAPHY; RADIOCOLLOIDS; TISSUE DISTRIBUTION; SPLEEN; TECHNETIUM 99; ALBUMINS; BONE MARROW; COMPARATIVE EVALUATIONS; IMAGES; ISOMERIC NUCLEI; ISOTOPE APPLICATIONS; PARTICLE SIZE; SKELETON; SULFUR; TIME DEPENDENCE; USA; ANIMAL TISSUES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; COLLOIDS; DIAGNOSTIC TECHNIQUES; DIGESTIVE SYSTEM; DISPERSIONS; DISTRIBUTION; ELEMENTS; GLANDS; HEMATOPOIETIC SYSTEM; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MEDICINE; NONMETALS; NORTH AMERICA; NUCLEAR MEDICINE; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; PROTEINS; RADIOISOTOPES; RADIOLOGY; SIZE; TECHNETIUM ISOTOPES; TISSUES; YEARS LIVING RADIOISOTOPES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics; 551001 - Physiological Systems- Tracer Techniques

Citation Formats

Klingensmith, W C, Spitzer, V M, Fritzberg, A R, and Kuni, C C. Normal appearance and reproducibility of liver-spleen studies with /sup 99m/Tc sulfur colloid and /sup 99m/Tc microalbumin colloid. United States: N. p., 1983. Web.
Klingensmith, W C, Spitzer, V M, Fritzberg, A R, & Kuni, C C. Normal appearance and reproducibility of liver-spleen studies with /sup 99m/Tc sulfur colloid and /sup 99m/Tc microalbumin colloid. United States.
Klingensmith, W C, Spitzer, V M, Fritzberg, A R, and Kuni, C C. 1983. "Normal appearance and reproducibility of liver-spleen studies with /sup 99m/Tc sulfur colloid and /sup 99m/Tc microalbumin colloid". United States.
@article{osti_6148327,
title = {Normal appearance and reproducibility of liver-spleen studies with /sup 99m/Tc sulfur colloid and /sup 99m/Tc microalbumin colloid},
author = {Klingensmith, W C and Spitzer, V M and Fritzberg, A R and Kuni, C C},
abstractNote = {In order to determine the normal biodistribution and reproducibility of /sup 99m/Tc sulfur colloid and /sup 99m/Tc microalbumin colloid, each of ten normal subjects was studied twice with each of the two agents. In overexposed delayed analog images of the anterior chest, some thyroid radioactivity was demonstrated in all of 20 microalbumin colloid studies and in none of 20 sulfur colloid studies; lung radioactivity was seen in 19 of 20 (95%) sulfur colloid studies and in none of the microalbumin colloid studies (both p less than 0.001). Delayed digital images showed that the sulfur colloid gave a higher lung-to-heart ratio, a higher lung-to-liver ratio, and a lower bone marrow-to-liver ratio compared with microalbumin colloid (all p less than 0.05). In general, reproducibility was poor for both agents. We conclude that while there are some differences between these two radiocolloids, the differences do not indicate a superiority of the newer Tc-99m microalbumin colloid over the established Tc-99m sulfur colloid for liver-spleen imaging.},
doi = {},
url = {https://www.osti.gov/biblio/6148327}, journal = {J. Nucl. Med.; (United States)},
number = ,
volume = 24:1,
place = {United States},
year = {Sat Jan 01 00:00:00 EST 1983},
month = {Sat Jan 01 00:00:00 EST 1983}
}