Aflatoxin B1 induced hepatic neoplasia in Great Lakes coho salmon

Journal Article · Tue Nov 01 00:00:00 EST 1988 · Bull. Environ. Contam. Toxicol.; (United States)

DOI:https://doi.org/10.1007/BF02021027· OSTI ID:6143118

Black, J J; Maccubbin, A E; Myers, H K; Zeigel, R F

There is considerable interest in the development of fish models for carcinogen bioassays and the study of chemically induced cancer in wild fish species. Among salmonid species, rainbow trout have mainly been used for carcinogenesis research, in part due to the role played by this species in the discovery of the carcinogenic action of aflatoxin B1 (AFB1). Recently, apparatus and methodology for microinjection of salmonid fish embryos with chemical carcinogens has been described. Because eggs produced by Pacific salmon are relatively much larger than those of rainbow trout, they would provide an attractive subject for embryo microinjection. The Great Lakes are annually stocked with large numbers of coho salmon. It has been recommended to use coho salmon as an indicator for monitoring ecosystem health in the Great Lakes, because stockings throughout health in the Great Lakes, because stockings throughout the Great Lakes are from a common genetic strain and in the lake environment they have a defined food source and life cycle. These considerations led the authors to test coho salmon for their sensitivity to the potent hepatocarcinogen, AFB1. The present report describes in preliminary form, the results of these experiments.

• Research Organization: Roswell Park Memorial Institute, Buffalo, NY (USA)
• OSTI ID: 6143118
• Journal Information: Bull. Environ. Contam. Toxicol.; (United States), Vol. 41:5
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AFLATOXIN
BIOLOGICAL EFFECTS
NEOPLASMS
HISTOLOGY
CELL PROLIFERATION
DOSE-RESPONSE RELATIONSHIPS
EGGS
GREAT LAKES
LIVER
MORTALITY
SALMON
ANADROMOUS FISHES
ANIMALS
ANTIGENS
AQUATIC ORGANISMS
BODY
DIGESTIVE SYSTEM
DISEASES
FISHES
GLANDS
LAKES
MATERIALS
ORGANS
SURFACE WATERS
TOXIC MATERIALS
TOXINS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology