Noninvasive determination of respiratory ozone absorption: Development of a fast-responding ozone analyzer. Research report, Jun 88-Apr 90

Ultman, J S; Ben-Jebria, A

Title: Noninvasive determination of respiratory ozone absorption: Development of a fast-responding ozone analyzer. Research report, Jun 88-Apr 90

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Abstract

An ozone analyzer and an ozone bolus generator were developed and tested for future use in noninvasive measurements of ozone absorption along the human respiratory tract using the bolus-response technique. The analyzer, based on the chemiluminescent reaction of ozone with 2-methyl-2-butene, is sufficiently rapid and sensitive to measure changes in ozone concentration during a four-second breathing period at quiet respiratory flowrates of 300 mL/sec in human subjects. Its performance characteristics include a 90 percent step-response time of 110 msec, a linear calibration from 0.03 to 10 ppm ozone, a signal-to-noise ratio of 30 at 0.5 ppm ozone, and a minimum detection limit of 0.017 ppm ozone. The ozone bolus generator can produce single boluses containing as little as 0.35 micro g ozone in a volume of 19 mL, with a peak ozone fraction of up to 4 ppm. The analyzer and bolus generator were tested in bolus-response experiments at steady air flowrates of 50 to 200 mL/sec in excised pig and sheep tracheas. Twenty-five to 50 percent of the ozone introduced into the trachea was absorbed. Analysis of the mathematical moments of the bolus input and response curves and comparison to predictions of a diffusion theory indicate that ozone absorptionmore »« less

Authors:: Ultman, J S; Ben-Jebria, A

Publication Date:: Tue Jan 01 00:00:00 EST 1991

Research Org.:: Pennsylvania State Univ., University Park, PA (United States). Dept. of Chemical Engineering

OSTI Identifier:: 6138647

Report Number(s):: PB-91-243220/XAB

Resource Type:: Technical Report

Resource Relation:: Other Information: Sponsored by Health Effects Inst., Cambridge, MA

Country of Publication:: United States

Language:: English

Subject:: 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; OZONE; CHEMICAL ANALYSIS; RESPIRATORY SYSTEM; SENSITIVITY; ABSORPTION; CHEMILUMINESCENCE; HUMIDITY; MAN; METABOLISM; SIGNAL-TO-NOISE RATIO; ANIMALS; LUMINESCENCE; MAMMALS; PRIMATES; VERTEBRATES; 560300* - Chemicals Metabolism & Toxicology

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                    Ultman, J S, and Ben-Jebria, A. Noninvasive determination of respiratory ozone absorption: Development of a fast-responding ozone analyzer. Research report, Jun 88-Apr 90.  United States: N. p., 1991. 
        Web.

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                    Ultman, J S, & Ben-Jebria, A. Noninvasive determination of respiratory ozone absorption: Development of a fast-responding ozone analyzer. Research report, Jun 88-Apr 90.  United States.

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                    Ultman, J S, and Ben-Jebria, A. 1991.  
        "Noninvasive determination of respiratory ozone absorption: Development of a fast-responding ozone analyzer. Research report, Jun 88-Apr 90".  United States.

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@article{osti_6138647,

  title        = {Noninvasive determination of respiratory ozone absorption: Development of a fast-responding ozone analyzer. Research report, Jun 88-Apr 90},

  author       = {Ultman, J S and Ben-Jebria, A},

  abstractNote = {An ozone analyzer and an ozone bolus generator were developed and tested for future use in noninvasive measurements of ozone absorption along the human respiratory tract using the bolus-response technique. The analyzer, based on the chemiluminescent reaction of ozone with 2-methyl-2-butene, is sufficiently rapid and sensitive to measure changes in ozone concentration during a four-second breathing period at quiet respiratory flowrates of 300 mL/sec in human subjects. Its performance characteristics include a 90 percent step-response time of 110 msec, a linear calibration from 0.03 to 10 ppm ozone, a signal-to-noise ratio of 30 at 0.5 ppm ozone, and a minimum detection limit of 0.017 ppm ozone. The ozone bolus generator can produce single boluses containing as little as 0.35 micro g ozone in a volume of 19 mL, with a peak ozone fraction of up to 4 ppm. The analyzer and bolus generator were tested in bolus-response experiments at steady air flowrates of 50 to 200 mL/sec in excised pig and sheep tracheas. Twenty-five to 50 percent of the ozone introduced into the trachea was absorbed. Analysis of the mathematical moments of the bolus input and response curves and comparison to predictions of a diffusion theory indicate that ozone absorption is limited by diffusion processes in the airway lumen.},

  doi          = {},

  url          = {https://www.osti.gov/biblio/6138647},
  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Tue Jan 01 00:00:00 EST 1991},

  month        = {Tue Jan 01 00:00:00 EST 1991}

}

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