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Title: Response of mesenteric blood vessels to irradiaion. [/sup 90/Sr. beta. applicator applied to exteriorized vessels]

Abstract

The response of mouse blood vessels to radiation has been studied by locally irradiating mesenteric vessels, in an exteriorized segment, using a strontium-90 ..beta.. applicator. Four different assays of damage were made when the animals were sacrificed from 6 weeks to 18 months after irradiaion. In all studies sham-irradiated animals were compared with those receiving 20, 30, and 45, Gy. Vein diameter was studied by direct observation vascular volume and permeability by isotope techniques, and the cellularity of the arterioles from histological sections. Within 3 months changes were seen in all these parameters, with a gradual recovery toward normal by 12 months, and a second phase of damage appearing at 18 months. The time course of changes in vascular permeability appeared to match the loss of endothelial cells lining the arterioles, but there was a significant correlation only at 6 weeks. Fibrosis was not seen before 12 months, but at 18 months the vessel walls were fibrosed, sclerotic, and occasionally the lumen was occluded. At no time was any change in the dependent ileum seen. The blood supply to this tissue was maintained in spite of the severe radiation damage in the vessels.

Authors:
; ;
Publication Date:
Research Org.:
Mount Vernon Hospital, Middlesex, England
OSTI Identifier:
6137824
Resource Type:
Journal Article
Journal Name:
Radiat. Res.; (United States)
Additional Journal Information:
Journal Volume: 77:2
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; BLOOD VESSELS; DELAYED RADIATION EFFECTS; FIBROSIS; RADIOINDUCTION; MORPHOLOGICAL CHANGES; NECROSIS; BETA SOURCES; BIOLOGICAL RECOVERY; CHROMIUM 51; EXPERIMENTAL DATA; HISTOLOGICAL TECHNIQUES; ISOLATED VALUES; LOCAL IRRADIATION; MESENTERY; MICE; PERMEABILITY; RADIATION INJURIES; STRONTIUM 90; TECHNETIUM 99; TRACER TECHNIQUES; ALKALINE EARTH ISOTOPES; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; CARDIOVASCULAR SYSTEM; CHROMIUM ISOTOPES; DATA; DATA FORMS; DISEASES; ELECTRON CAPTURE RADIOISOTOPES; EVEN-EVEN NUCLEI; EVEN-ODD NUCLEI; HOURS LIVING RADIOISOTOPES; INFORMATION; INJURIES; INTERMEDIATE MASS NUCLEI; IRRADIATION; ISOMERIC TRANSITION ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; MAMMALS; MEMBRANES; NUCLEI; NUMERICAL DATA; ODD-EVEN NUCLEI; PARTICLE SOURCES; PATHOLOGICAL CHANGES; RADIATION EFFECTS; RADIATION SOURCES; RADIOISOTOPES; RECOVERY; RODENTS; SEROUS MEMBRANES; STRONTIUM ISOTOPES; TECHNETIUM ISOTOPES; VERTEBRATES; YEARS LIVING RADIOISOTOPES; 560152* - Radiation Effects on Animals- Animals

Citation Formats

Hirst, D.G., Denekamp, J., and Travis, E.L. Response of mesenteric blood vessels to irradiaion. [/sup 90/Sr. beta. applicator applied to exteriorized vessels]. United States: N. p., 1979. Web. doi:10.2307/3575138.
Hirst, D.G., Denekamp, J., & Travis, E.L. Response of mesenteric blood vessels to irradiaion. [/sup 90/Sr. beta. applicator applied to exteriorized vessels]. United States. doi:10.2307/3575138.
Hirst, D.G., Denekamp, J., and Travis, E.L. Thu . "Response of mesenteric blood vessels to irradiaion. [/sup 90/Sr. beta. applicator applied to exteriorized vessels]". United States. doi:10.2307/3575138.
@article{osti_6137824,
title = {Response of mesenteric blood vessels to irradiaion. [/sup 90/Sr. beta. applicator applied to exteriorized vessels]},
author = {Hirst, D.G. and Denekamp, J. and Travis, E.L.},
abstractNote = {The response of mouse blood vessels to radiation has been studied by locally irradiating mesenteric vessels, in an exteriorized segment, using a strontium-90 ..beta.. applicator. Four different assays of damage were made when the animals were sacrificed from 6 weeks to 18 months after irradiaion. In all studies sham-irradiated animals were compared with those receiving 20, 30, and 45, Gy. Vein diameter was studied by direct observation vascular volume and permeability by isotope techniques, and the cellularity of the arterioles from histological sections. Within 3 months changes were seen in all these parameters, with a gradual recovery toward normal by 12 months, and a second phase of damage appearing at 18 months. The time course of changes in vascular permeability appeared to match the loss of endothelial cells lining the arterioles, but there was a significant correlation only at 6 weeks. Fibrosis was not seen before 12 months, but at 18 months the vessel walls were fibrosed, sclerotic, and occasionally the lumen was occluded. At no time was any change in the dependent ileum seen. The blood supply to this tissue was maintained in spite of the severe radiation damage in the vessels.},
doi = {10.2307/3575138},
journal = {Radiat. Res.; (United States)},
number = ,
volume = 77:2,
place = {United States},
year = {1979},
month = {2}
}