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Title: Influence of testicular microanatomy on the potential genetic dose from internally deposited /sup 239/Pu citrate in Chinese hamster, mouse, and man. [Measurements in mice and hamsters of dose distributions used in calculations for man based on measured anatomical features of human testes]

Abstract

The localization, retention, and microdistribution of /sup 239/Pu citrate in the testes of the Chinese hamster were determined. Testicular morphometric measurements were made in adult mice and Chinese hamsters as well as in aged, adult, and immature humans. Calculations based on these morphometric measurements and a nonuniform microdistribution of plutonium indicated that the radiation dose to spermatogonia of man was less than that predicted from a uniform distribution of activity. This contrasts with the enhanced dose to the spermatogonia in mouse and Chinese hamsters produced by the unique microanatomy and nonuniform deposition of plutonium in the testes of rodents. Levels of /sup 239/Pu which induced marked life shortening and increased cancer incidence caused no significant increase in the frequency of mitotic chromosome aberrations in spermatogonia.

Authors:
; ;
Publication Date:
Research Org.:
Lovelace Biomedical and Environmental Research Inst., Albuquerque, NM
OSTI Identifier:
6137690
Resource Type:
Journal Article
Journal Name:
Radiat. Res.; (United States)
Additional Journal Information:
Journal Volume: 77:2
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CHROMOSOMAL ABERRATIONS; RADIOINDUCTION; PLUTONIUM 239; BIOLOGICAL LOCALIZATION; MICRODOSIMETRY; RETENTION; SPERMATOGONIA; RADIATION DOSES; RADIATION INJURIES; TESTES; ANATOMY; RADIONUCLIDE KINETICS; AGE GROUPS; CITRATES; EXPERIMENTAL DATA; HAMSTERS; INJECTION; ISOLATED VALUES; MAN; MICE; MONTE CARLO METHOD; PLUTONIUM COMPOUNDS; ACTINIDE COMPOUNDS; ACTINIDE ISOTOPES; ACTINIDE NUCLEI; ALPHA DECAY RADIOISOTOPES; ANIMALS; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BODY; CARBOXYLIC ACID SALTS; DATA; DATA FORMS; DOSES; DOSIMETRY; EVEN-ODD NUCLEI; GAMETES; GERM CELLS; GONADS; HEAVY NUCLEI; INFORMATION; INJURIES; INTAKE; ISOTOPES; MALE GENITALS; MAMMALS; MUTATIONS; NUCLEI; NUMERICAL DATA; ORGANS; PLUTONIUM ISOTOPES; PRIMATES; RADIATION EFFECTS; RADIOISOTOPES; RODENTS; TRANSURANIUM COMPOUNDS; VERTEBRATES; YEARS LIVING RADIOISOTOPES; 560172* - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987); 560171 - Radiation Effects- Nuclide Kinetics & Toxicology- Man- (-1987); 560162 - Radionuclide Effects, Kinetics, & Toxicology- Animals, Plants, Microorganisms, & Cells; 560161 - Radionuclide Effects, Kinetics, & Toxicology- Man

Citation Formats

Brooks, A.L., Diel, J.H., and McClellan, R.O. Influence of testicular microanatomy on the potential genetic dose from internally deposited /sup 239/Pu citrate in Chinese hamster, mouse, and man. [Measurements in mice and hamsters of dose distributions used in calculations for man based on measured anatomical features of human testes]. United States: N. p., 1979. Web. doi:10.2307/3575141.
Brooks, A.L., Diel, J.H., & McClellan, R.O. Influence of testicular microanatomy on the potential genetic dose from internally deposited /sup 239/Pu citrate in Chinese hamster, mouse, and man. [Measurements in mice and hamsters of dose distributions used in calculations for man based on measured anatomical features of human testes]. United States. doi:10.2307/3575141.
Brooks, A.L., Diel, J.H., and McClellan, R.O. Thu . "Influence of testicular microanatomy on the potential genetic dose from internally deposited /sup 239/Pu citrate in Chinese hamster, mouse, and man. [Measurements in mice and hamsters of dose distributions used in calculations for man based on measured anatomical features of human testes]". United States. doi:10.2307/3575141.
@article{osti_6137690,
title = {Influence of testicular microanatomy on the potential genetic dose from internally deposited /sup 239/Pu citrate in Chinese hamster, mouse, and man. [Measurements in mice and hamsters of dose distributions used in calculations for man based on measured anatomical features of human testes]},
author = {Brooks, A.L. and Diel, J.H. and McClellan, R.O.},
abstractNote = {The localization, retention, and microdistribution of /sup 239/Pu citrate in the testes of the Chinese hamster were determined. Testicular morphometric measurements were made in adult mice and Chinese hamsters as well as in aged, adult, and immature humans. Calculations based on these morphometric measurements and a nonuniform microdistribution of plutonium indicated that the radiation dose to spermatogonia of man was less than that predicted from a uniform distribution of activity. This contrasts with the enhanced dose to the spermatogonia in mouse and Chinese hamsters produced by the unique microanatomy and nonuniform deposition of plutonium in the testes of rodents. Levels of /sup 239/Pu which induced marked life shortening and increased cancer incidence caused no significant increase in the frequency of mitotic chromosome aberrations in spermatogonia.},
doi = {10.2307/3575141},
journal = {Radiat. Res.; (United States)},
number = ,
volume = 77:2,
place = {United States},
year = {1979},
month = {2}
}