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Title: Studies on aerosols. I. Reduction of dust deposition in lungs of rabbits by aqueous aerosols

Abstract

Rabbits were exposed to air containing 0.01 to 0.04 mg/liter zinc silicate dust with a mean diameter of 0.9 ..mu..m. Irregular breathing with some cyanosis after 2 hr was observed. Pulmonary changes after 4.5 to 5 hr included bronchitis, patchy atelectasis, emphysema, interstitial pneumonitis (thickening of septa, moderate congestion, infiltration of mononuclear cells and polymorphonuclear leukocytes). After 1, 7, or 14 days recovery there were no or only slight pulmonary problems. There was localization of particles at surfaces facing, deflecting or slowing air currents, particularly near pleura and hilus and less in central portion of lobes. Rabbits exposed to above dust plus aqueous wetting agent aerosol averaging 0.5 ..mu..m in diameter showed no cyanosis or marked respiratory difficulty. Rabbits showed less of above pulmonary changes and lesser amount of dust in lungs, particularly in alveoli and alveolar ducts. Most particles were cleared in 1 day in both groups, especially aerosol group, and essentially were all gone after 7 days. Differences were primarily due to coating of particles with liquid (increased size) and aggregation.

Authors:
; ;
Publication Date:
OSTI Identifier:
6131971
Resource Type:
Journal Article
Journal Name:
J. Ind. Hyg. Toxicol.; (United States)
Additional Journal Information:
Journal Volume: 30
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; DUSTS; DEPOSITION; AEROSOLS; BRONCHITIS; CLEARANCE; EMPHYSEMA; LUNGS; PARTICLE SIZE; PARTICLES; PATHOLOGICAL CHANGES; PNEUMONITIS; RABBITS; RESPIRATORY SYSTEM DISEASES; RETENTION; ZINC SILICATES; ANIMALS; BODY; COLLOIDS; DISEASES; DISPERSIONS; MAMMALS; ORGANS; OXYGEN COMPOUNDS; RESPIRATORY SYSTEM; SILICATES; SILICON COMPOUNDS; SIZE; SOLS; VERTEBRATES; ZINC COMPOUNDS; 560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)

Citation Formats

Dautrebande, L, Highman, B, and Alford, W C. Studies on aerosols. I. Reduction of dust deposition in lungs of rabbits by aqueous aerosols. United States: N. p., 1948. Web.
Dautrebande, L, Highman, B, & Alford, W C. Studies on aerosols. I. Reduction of dust deposition in lungs of rabbits by aqueous aerosols. United States.
Dautrebande, L, Highman, B, and Alford, W C. 1948. "Studies on aerosols. I. Reduction of dust deposition in lungs of rabbits by aqueous aerosols". United States.
@article{osti_6131971,
title = {Studies on aerosols. I. Reduction of dust deposition in lungs of rabbits by aqueous aerosols},
author = {Dautrebande, L and Highman, B and Alford, W C},
abstractNote = {Rabbits were exposed to air containing 0.01 to 0.04 mg/liter zinc silicate dust with a mean diameter of 0.9 ..mu..m. Irregular breathing with some cyanosis after 2 hr was observed. Pulmonary changes after 4.5 to 5 hr included bronchitis, patchy atelectasis, emphysema, interstitial pneumonitis (thickening of septa, moderate congestion, infiltration of mononuclear cells and polymorphonuclear leukocytes). After 1, 7, or 14 days recovery there were no or only slight pulmonary problems. There was localization of particles at surfaces facing, deflecting or slowing air currents, particularly near pleura and hilus and less in central portion of lobes. Rabbits exposed to above dust plus aqueous wetting agent aerosol averaging 0.5 ..mu..m in diameter showed no cyanosis or marked respiratory difficulty. Rabbits showed less of above pulmonary changes and lesser amount of dust in lungs, particularly in alveoli and alveolar ducts. Most particles were cleared in 1 day in both groups, especially aerosol group, and essentially were all gone after 7 days. Differences were primarily due to coating of particles with liquid (increased size) and aggregation.},
doi = {},
url = {https://www.osti.gov/biblio/6131971}, journal = {J. Ind. Hyg. Toxicol.; (United States)},
number = ,
volume = 30,
place = {United States},
year = {Thu Jan 01 00:00:00 EST 1948},
month = {Thu Jan 01 00:00:00 EST 1948}
}