Influence of chronic prolactin suppression during puberty on the development of dimethylbenz(a)anthracene-induced mammary tumors (41163). [Rats]

Journal Article · Mon Jun 01 00:00:00 EDT 1981 · Proc. Soc. Exp. Biol. Med.; (United States)

DOI:https://doi.org/10.3181/00379727-167-41163· OSTI ID:6119266

Cohen, L A

In order to assess the effect of early prolactin suppression on the subsequent development of dimethylbenz(a)anthracene (DMBA)-induced mammary cancers, the dopamine agonist, CB-154, was chronically administered to female Sprague-Dawley rats from Day 35 to Day 50 of age. DMBA was then administered and tumor development assessed over a 25-week period. It was found that animals treated with CB-154 exhibited decreased tumor incidence, a longer latent period, and fewer tumors/animal, when compared to vehicle controls. These results are consistent with the hypothesis that the sensitivity of the mammary gland to polycyclic aromatic hydrocarbon (PAH) carcinogenesis is determined by the level of differentiation of the gland at the time of carcinogen administration. Accordingly, perturbations in prolactin secretion patterns, early in life, may accelerate or retard the differentiation of the mammary gland thereby rendering it less susceptible to the carcinogenic effects of PAH.

• Research Organization: American Health Foundation, Valhalla, NY
• OSTI ID: 6119266
• Journal Information: Proc. Soc. Exp. Biol. Med.; (United States), Vol. 167:2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
DIMETHYLBENZANTHRACENE
CARCINOGENESIS
LTH
BIOLOGICAL EFFECTS
ADOLESCENTS
INHIBITION
MAMMARY GLANDS
NEOPLASMS
RATS
AGE GROUPS
ANIMALS
AROMATICS
BODY
CONDENSED AROMATICS
DISEASES
GLANDS
GONADOTROPINS
HORMONES
MAMMALS
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
PEPTIDE HORMONES
PITUITARY HORMONES
RODENTS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)