skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Long-term NO/sub 2/ exposure of mice in the presence and absence of vitamin E. II. Effect of glutathione peroxidase

Abstract

One hundred and twenty female mice fed diets containing various levels of vitamin E were continuously exposed to 0.5 ppM, 1.0 ppM nitrogen dioxide (NO/sub 2/), and filtered air for 17 months. Blood, lung, and liver tissues were assayed for glutathione peroxidase (GSH-peroxidase) activity. Exposure to 0.5 ppM NO/sub 2/ did not affect blood and lung GSH-peroxidase activity; 1.0 ppM NO/sub 2/ exposure however, caused suppression of the enzyme. A combination of vitamin E deficiency and 1.0 ppM NO/sub 2/ exposure resulted in the lowest GSH-peroxidase activities in the blood and lung. High levels of vitamin E in the diet resulted in elevated GSH-peroxidase in the blood and lung. Liver GSH-peroxidase activity was unaffected by either dietary vitamin E or NO/sub 2/ exposure.

Authors:
;
Publication Date:
OSTI Identifier:
6110474
Resource Type:
Journal Article
Journal Name:
Arch. Environ. Health; (United States)
Additional Journal Information:
Journal Volume: 33:6
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 59 BASIC BIOLOGICAL SCIENCES; NITROGEN DIOXIDE; BIOLOGICAL EFFECTS; CHRONIC EXPOSURE; PEROXIDASES; BIOCHEMISTRY; VITAMIN E; NUTRITIONAL DEFICIENCY; BLOOD; ENZYME ACTIVITY; FEMALES; GLUTATHIONE; LIVER; LUNGS; MICE; ANIMALS; BIOLOGICAL MATERIALS; BODY; BODY FLUIDS; CARBOXYLIC ACIDS; CHALCOGENIDES; CHEMISTRY; DIGESTIVE SYSTEM; DRUGS; ENZYMES; GLANDS; HETEROCYCLIC ACIDS; HETEROCYCLIC COMPOUNDS; MAMMALS; MATERIALS; NITROGEN COMPOUNDS; NITROGEN OXIDES; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; OXIDES; OXIDOREDUCTASES; OXYGEN COMPOUNDS; PEPTIDES; POLYPEPTIDES; PORPHYRINS; PROTEINS; RADIOPROTECTIVE SUBSTANCES; RESPIRATORY SYSTEM; RODENTS; VERTEBRATES; VITAMINS; 560306* - Chemicals Metabolism & Toxicology- Man- (-1987); 550200 - Biochemistry

Citation Formats

Ayaz, K L, and Csallany, A S. Long-term NO/sub 2/ exposure of mice in the presence and absence of vitamin E. II. Effect of glutathione peroxidase. United States: N. p., 1978. Web. doi:10.1080/00039896.1978.10667350.
Ayaz, K L, & Csallany, A S. Long-term NO/sub 2/ exposure of mice in the presence and absence of vitamin E. II. Effect of glutathione peroxidase. United States. https://doi.org/10.1080/00039896.1978.10667350
Ayaz, K L, and Csallany, A S. Wed . "Long-term NO/sub 2/ exposure of mice in the presence and absence of vitamin E. II. Effect of glutathione peroxidase". United States. https://doi.org/10.1080/00039896.1978.10667350.
@article{osti_6110474,
title = {Long-term NO/sub 2/ exposure of mice in the presence and absence of vitamin E. II. Effect of glutathione peroxidase},
author = {Ayaz, K L and Csallany, A S},
abstractNote = {One hundred and twenty female mice fed diets containing various levels of vitamin E were continuously exposed to 0.5 ppM, 1.0 ppM nitrogen dioxide (NO/sub 2/), and filtered air for 17 months. Blood, lung, and liver tissues were assayed for glutathione peroxidase (GSH-peroxidase) activity. Exposure to 0.5 ppM NO/sub 2/ did not affect blood and lung GSH-peroxidase activity; 1.0 ppM NO/sub 2/ exposure however, caused suppression of the enzyme. A combination of vitamin E deficiency and 1.0 ppM NO/sub 2/ exposure resulted in the lowest GSH-peroxidase activities in the blood and lung. High levels of vitamin E in the diet resulted in elevated GSH-peroxidase in the blood and lung. Liver GSH-peroxidase activity was unaffected by either dietary vitamin E or NO/sub 2/ exposure.},
doi = {10.1080/00039896.1978.10667350},
url = {https://www.osti.gov/biblio/6110474}, journal = {Arch. Environ. Health; (United States)},
number = ,
volume = 33:6,
place = {United States},
year = {1978},
month = {11}
}