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Title: Relationship between repair processes and mutation induction in bacteria. [UV radiation; methyl methanesulfonate; N-methyl-N/sup 1/-nitro-N-nitrosoguanidine; N-methyl-N-nitrosourea; N-ethyl-N-nitrosourea; ethyl methanesulfanate; N-ethyl-nitrosoguanidine; 4-nitroquinoline 1-oxide]

Abstract

The main repair and replication-associated processes that can influence the induction of mutations by various mutagens in bacteria are reviewed. These include both constitutive and induced, error-free and error-prone systems. The mutation yield from a treatment with a mutagen can be markedly affected by which of these systems is operating in a given bacterial species or strain. The effect of these systems on mutation induction by ultraviolet light, monofunctional alkylating agents, base analogues, and frameshift mutagens is discussed in some detail. The bearing of these studies on the practical problems of estimating hazards is briefly considered. 79 references.

Authors:
Publication Date:
Research Org.:
Oak Ridge National Lab., TN (USA)
Sponsoring Org.:
USDOE
OSTI Identifier:
6098705
Report Number(s):
CONF-790676-1
DOE Contract Number:  
W-7405-ENG-26
Resource Type:
Conference
Resource Relation:
Conference: Conference on DNA repair and mutagenesis in bacteria, Atlanta, GA, USA, 25 Jun 1979
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 59 BASIC BIOLOGICAL SCIENCES; BACTERIA; MUTAGENESIS; BIOLOGICAL MODELS; MUTAGENS; MUTATIONS; BIOLOGICAL REPAIR; ULTRAVIOLET RADIATION; ALKYLATING AGENTS; BIOLOGICAL EFFECTS; DNA REPLICATION; ESCHERICHIA COLI; HEALTH HAZARDS; METHYL METHANESULFONATE; MUTAGEN SCREENING; PROTEUS; RISK ASSESSMENT; SALMONELLA; ANTIMITOTIC DRUGS; BIOLOGICAL RECOVERY; DRUGS; ELECTROMAGNETIC RADIATION; ESTERS; HAZARDS; MICROORGANISMS; NUCLEIC ACID REPLICATION; ORGANIC COMPOUNDS; ORGANIC SULFUR COMPOUNDS; RADIATIONS; RECOVERY; REPAIR; SCREENING; SULFONIC ACID ESTERS; 560302* - Chemicals Metabolism & Toxicology- Microorganisms- (-1987); 560400 - Other Environmental Pollutant Effects; 550400 - Genetics

Citation Formats

Kimball, R F. Relationship between repair processes and mutation induction in bacteria. [UV radiation; methyl methanesulfonate; N-methyl-N/sup 1/-nitro-N-nitrosoguanidine; N-methyl-N-nitrosourea; N-ethyl-N-nitrosourea; ethyl methanesulfanate; N-ethyl-nitrosoguanidine; 4-nitroquinoline 1-oxide]. United States: N. p., 1979. Web.
Kimball, R F. Relationship between repair processes and mutation induction in bacteria. [UV radiation; methyl methanesulfonate; N-methyl-N/sup 1/-nitro-N-nitrosoguanidine; N-methyl-N-nitrosourea; N-ethyl-N-nitrosourea; ethyl methanesulfanate; N-ethyl-nitrosoguanidine; 4-nitroquinoline 1-oxide]. United States.
Kimball, R F. 1979. "Relationship between repair processes and mutation induction in bacteria. [UV radiation; methyl methanesulfonate; N-methyl-N/sup 1/-nitro-N-nitrosoguanidine; N-methyl-N-nitrosourea; N-ethyl-N-nitrosourea; ethyl methanesulfanate; N-ethyl-nitrosoguanidine; 4-nitroquinoline 1-oxide]". United States. https://www.osti.gov/servlets/purl/6098705.
@article{osti_6098705,
title = {Relationship between repair processes and mutation induction in bacteria. [UV radiation; methyl methanesulfonate; N-methyl-N/sup 1/-nitro-N-nitrosoguanidine; N-methyl-N-nitrosourea; N-ethyl-N-nitrosourea; ethyl methanesulfanate; N-ethyl-nitrosoguanidine; 4-nitroquinoline 1-oxide]},
author = {Kimball, R F},
abstractNote = {The main repair and replication-associated processes that can influence the induction of mutations by various mutagens in bacteria are reviewed. These include both constitutive and induced, error-free and error-prone systems. The mutation yield from a treatment with a mutagen can be markedly affected by which of these systems is operating in a given bacterial species or strain. The effect of these systems on mutation induction by ultraviolet light, monofunctional alkylating agents, base analogues, and frameshift mutagens is discussed in some detail. The bearing of these studies on the practical problems of estimating hazards is briefly considered. 79 references.},
doi = {},
url = {https://www.osti.gov/biblio/6098705}, journal = {},
number = ,
volume = ,
place = {United States},
year = {Mon Jan 01 00:00:00 EST 1979},
month = {Mon Jan 01 00:00:00 EST 1979}
}

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