Modulation of human alveolar macrophage properties by ozone exposure in vitro
The study investigated changes in human alveolar macrophage (HAM) function after exposure in vitro to ozone (O3)(0.1-1.0 ppm for 2-4 hr). The functions studied reflect concern that O3 is detrimental to host defense mechanisms in the bronchoalveolar spaces. Exposure of HAM to O3 caused a concentration-dependent increase in release of prostaglandin E2(PGE2), an important modulator of inflammation, phagocytosis, and oxidative burst. Although phagocytosis of particulate immune complexes was decreased by O3, the authors found no change in the quantity of Fc receptors and complement receptors on the HAM surface. Superoxide (O2) production in response to phorbol ester was reduced after exposure of HAM to O3 while the basal O2 release in response to plastic adherence was not affected. Growth inhibition of the opportunistic yeast Cryptococcus neoformans by HAM was not affected by O3 exposure. The production of inflammatory mediators and immune modulators such as tumor necrosis factor-alpha, interleukin 1, and interleukin 6 were not induced by exposure to O3. However, compared to controls, O3-exposed HAM produced significantly lower levels of these cytokines when simulated with bacterial lipopolysaccharide (LPS).
- Research Organization:
- Environmental Protection Agency, Research Triangle Park, NC (United States). Health Effects Research Lab.
- OSTI ID:
- 6097141
- Report Number(s):
- PB-92-113281/XAB
- Resource Relation:
- Other Information: Pub. in Toxicology and Applied Pharmacology, v110 n3 p403-415 1991. Prepared in cooperation with ABB Environmental Services, Inc., Chapel Hill, NC., Cincinnati Univ. Medical Center, OH., and North Carolina Univ. at Chapel Hill
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
MACROPHAGES
PHAGOCYTOSIS
OZONE
TOXICITY
PHORBOL ESTERS
BIOLOGICAL EFFECTS
AIR POLLUTION
COMPLEMENT
DOSE-RESPONSE RELATIONSHIPS
ELECTROPHORESIS
IN VITRO
MAN
PROSTAGLANDINS
YEASTS
ANIMAL CELLS
ANIMALS
CARCINOGENS
CONNECTIVE TISSUE CELLS
ESTERS
EUMYCOTA
FUNGI
MAMMALS
MICROORGANISMS
ORGANIC COMPOUNDS
PHAGOCYTES
PLANTS
POLLUTION
PRIMATES
PROTEINS
SOMATIC CELLS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology