Toxicity and fetotoxicity of TCDD, TCDF and PCB isomers in rhesus macaques (Macaca mulatta)
In rhesus macaques (Macaca mulatta), consumption of food containing commercial polychlorinated biphenyl (PCB) mixtures, some pure polychlorobiphenyl congeners, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), and 2,3,7,8-tetrachlorodibenzofuran (TCDF) caused the same clinical toxic manifestations and histopathologic lesions, although the potencies of the toxicants covered a range of five orders of magnitude. Recovery from poisoning by 3,4,3',4'-tetrachlorobiphenyl (34TCB) or TCDF was rapid, whereas recovery from poisoning by Aroclor 1242, 3,4,5,3',4',5'-hexachlorobiphenyl (345HCB), or TCDD was protracted, if it occurred at all. 34TCB did not appreciably accumulate in body fat, but the level of 345HCB in fat rose steadily during ingestion. Among the symmetrical tetra- and hexachlorobiphenyl isomers tested, subacute oral toxicity could be demonstrated only for those without ortho chlorine substitutions. The principal demonstrable histopathological lesions, bone marrow excepted, were metaplasias in some specialized epithelial structures, such as sebaceous glands, nail beds, gastric mucosa, ameloblast, and thymic corpuscles. These changes were interpreted as toxicant-induced, reversible redirection of differentiation. this aberration was wholly reversible. TCDD and 34TCB caused abortions when given in one or a few oral doses early in pregnancy. At the total doses used (1 or 5 g/kg of body weight for TCDD, 3 or 0.6 mg/kg of body weight for 34TCB), maternal toxicity was frequently apparent subsequent to the abortion.
- Research Organization:
- Oregon Regional Primate Research Institute, Beaverton
- OSTI ID:
- 6080185
- Journal Information:
- Environ. Health Perspect.; (United States), Vol. 60
- Country of Publication:
- United States
- Language:
- English
Similar Records
Relative potency based on hepatic enzyme induction predicts immunosuppressive effects of a mixture of PCDDS/PCDFS and PCBS
Role of the Ah locus in suppression of cytotoxic T lymphocyte activity by halogenated aromatic hydrocarbons (PCBs and TCDD): Structure-activity relationships and effects in C57Bl/6 mice congenic at the Ah locus
Related Subjects
BENZOFURANS
TOXICITY
CHLORINATED AROMATIC HYDROCARBONS
FETUSES
SENSITIVITY
BIOLOGICAL ACCUMULATION
BIOLOGICAL RECOVERY
BONE MARROW
DIOXIN
EPITHELIUM
MIXTURES
MONKEYS
PATHOLOGICAL CHANGES
REPRODUCTIVE DISORDERS
ANIMAL TISSUES
ANIMALS
AROMATICS
BODY
DISPERSIONS
FURANS
HALOGENATED AROMATIC HYDROCARBONS
HEMATOPOIETIC SYSTEM
HETEROCYCLIC COMPOUNDS
MAMMALS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
PRIMATES
RECOVERY
TISSUES
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)