Effect of acetazolamide on cerebral blood flow in subacute and chronic cerebrovascular disease

Journal Article · Tue Sep 01 00:00:00 EDT 1987 · Stroke; (United States)

DOI:https://doi.org/10.1161/01.STR.18.5.887· OSTI ID:6075627

Hojer-Pedersen, E

Acetazolamide increases cerebral blood flow. The generalized and regional changes in blood flow after administration of acetazolamide were evaluated by the xenon-133 inhalation technique in a series of patients with subacute or chronic focal cerebral ischemia. Acetazolamide augmented interhemispheric asymmetry of cerebral blood flow in patients with unilateral occlusion of major cerebral arteries, whereas no significant side-to-side asymmetry was evident in patients with minor arterial lesions. Low flow areas in relation to computed tomography-verified infarcts tended to be larger after administration of acetazolamide. Hyperfrontality was present at rest and during stimulation with acetazolamide. A decline of cerebral blood flow with advancing age was greater in patients than in normal controls. The vasodilator response to acetazolamide did not change with age.

• Research Organization: Odense Univ. Hospital, Denmark
• OSTI ID: 6075627
• Journal Information: Stroke; (United States), Vol. 18:5
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ACETAMIDE
BIOLOGICAL EFFECTS
BRAIN
BLOOD FLOW
VASCULAR DISEASES
DIAGNOSIS
AGE DEPENDENCE
COMPUTERIZED TOMOGRAPHY
ENZYME INHIBITORS
PATIENTS
XENON 133
AMIDES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CENTRAL NERVOUS SYSTEM
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
EVEN-ODD NUCLEI
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
NERVOUS SYSTEM
NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
RADIOISOTOPES
TOMOGRAPHY
XENON ISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics