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Title: ROC (Receiver Operating Characteristics) study of maximum likelihood estimator human brain image reconstructions in PET (Positron Emission Tomography) clinical practice

Abstract

This paper will report on the progress to date in carrying out Receiver Operating Characteristics (ROC) studies comparing Maximum Likelihood Estimator (MLE) and Filtered Backprojection (FBP) reconstructions of normal and abnormal human brain PET data in a clinical setting. A previous statistical study of reconstructions of the Hoffman brain phantom with real data indicated that the pixel-to-pixel standard deviation in feasible MLE images is approximately proportional to the square root of the number of counts in a region, as opposed to a standard deviation which is high and largely independent of the number of counts in FBP. A preliminary ROC study carried out with 10 non-medical observers performing a relatively simple detectability task indicates that, for the majority of observers, lower standard deviation translates itself into a statistically significant detectability advantage in MLE reconstructions. The initial results of ongoing tests with four experienced neurologists/nuclear medicine physicians are presented. Normal cases of {sup 18}F -- fluorodeoxyglucose (FDG) cerebral metabolism studies and abnormal cases in which a variety of lesions have been introduced into normal data sets have been evaluated. We report on the results of reading the reconstructions of 90 data sets, each corresponding to a single brain slice. It hasmore » become apparent that the design of the study based on reading single brain slices is too insensitive and we propose a variation based on reading three consecutive slices at a time, rating only the center slice. 9 refs., 2 figs., 1 tab.« less

Authors:
; ;  [1]; ; ; ; ;  [2]
  1. Lawrence Berkeley Lab., CA (USA)
  2. California Univ., Los Angeles, CA (USA)
Publication Date:
Research Org.:
Lawrence Berkeley Lab., CA (USA)
Sponsoring Org.:
DOE/ER
OSTI Identifier:
6071027
Report Number(s):
LBL-29711; CONF-9010220-17
ON: DE91005371; TRN: 91-004206
DOE Contract Number:  
AC03-76SF00098
Resource Type:
Conference
Resource Relation:
Conference: 1990 IEEE nuclear science symposium, Arlington, VA (USA), 23-27 Oct 1990
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BRAIN; POSITRON COMPUTED TOMOGRAPHY; GLUCOSE; METABOLISM; ACCURACY; FLUORINE 18; MAN; PHANTOMS; ALDEHYDES; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BODY; CARBOHYDRATES; CENTRAL NERVOUS SYSTEM; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; EMISSION COMPUTED TOMOGRAPHY; FLUORINE ISOTOPES; HEXOSES; HOURS LIVING RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LIGHT NUCLEI; MAMMALS; MOCKUP; MONOSACCHARIDES; NERVOUS SYSTEM; NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANS; PRIMATES; RADIOISOTOPES; SACCHARIDES; STRUCTURAL MODELS; TOMOGRAPHY; VERTEBRATES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics

Citation Formats

Llacer, J, Veklerov, E, Nolan, D, Grafton, S T, Mazziotta, J C, Hawkins, R A, Hoh, C K, and Hoffman, E J. ROC (Receiver Operating Characteristics) study of maximum likelihood estimator human brain image reconstructions in PET (Positron Emission Tomography) clinical practice. United States: N. p., 1990. Web.
Llacer, J, Veklerov, E, Nolan, D, Grafton, S T, Mazziotta, J C, Hawkins, R A, Hoh, C K, & Hoffman, E J. ROC (Receiver Operating Characteristics) study of maximum likelihood estimator human brain image reconstructions in PET (Positron Emission Tomography) clinical practice. United States.
Llacer, J, Veklerov, E, Nolan, D, Grafton, S T, Mazziotta, J C, Hawkins, R A, Hoh, C K, and Hoffman, E J. Mon . "ROC (Receiver Operating Characteristics) study of maximum likelihood estimator human brain image reconstructions in PET (Positron Emission Tomography) clinical practice". United States. https://www.osti.gov/servlets/purl/6071027.
@article{osti_6071027,
title = {ROC (Receiver Operating Characteristics) study of maximum likelihood estimator human brain image reconstructions in PET (Positron Emission Tomography) clinical practice},
author = {Llacer, J and Veklerov, E and Nolan, D and Grafton, S T and Mazziotta, J C and Hawkins, R A and Hoh, C K and Hoffman, E J},
abstractNote = {This paper will report on the progress to date in carrying out Receiver Operating Characteristics (ROC) studies comparing Maximum Likelihood Estimator (MLE) and Filtered Backprojection (FBP) reconstructions of normal and abnormal human brain PET data in a clinical setting. A previous statistical study of reconstructions of the Hoffman brain phantom with real data indicated that the pixel-to-pixel standard deviation in feasible MLE images is approximately proportional to the square root of the number of counts in a region, as opposed to a standard deviation which is high and largely independent of the number of counts in FBP. A preliminary ROC study carried out with 10 non-medical observers performing a relatively simple detectability task indicates that, for the majority of observers, lower standard deviation translates itself into a statistically significant detectability advantage in MLE reconstructions. The initial results of ongoing tests with four experienced neurologists/nuclear medicine physicians are presented. Normal cases of {sup 18}F -- fluorodeoxyglucose (FDG) cerebral metabolism studies and abnormal cases in which a variety of lesions have been introduced into normal data sets have been evaluated. We report on the results of reading the reconstructions of 90 data sets, each corresponding to a single brain slice. It has become apparent that the design of the study based on reading single brain slices is too insensitive and we propose a variation based on reading three consecutive slices at a time, rating only the center slice. 9 refs., 2 figs., 1 tab.},
doi = {},
url = {https://www.osti.gov/biblio/6071027}, journal = {},
number = ,
volume = ,
place = {United States},
year = {1990},
month = {10}
}

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