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Title: Postnatal pattern of ornithine decarboxylase activity reveals a disparity of rat brain regeneration capacity after prenatal X-ray or 5-azacytidine treatment

Abstract

Pregnant Wistar rats were treated on the 15th day of gestation either with 1.4 Gy X-radiation, or with 2 X 2.5 mg 5-azacytidine per kg body weight. X-irradiation caused negligible mortality among the offspring, despite of a 35% reduction of brain weights. The course of brain ornithine decarboxylase activity exhibited two breaches within 5 days after birth, each followed by recovery to control levels. After 5-azacytidine treatment brain weights were reduced by 16% only, but two thirds of the young died within a short time after birth. During three days following birth, the activity of ornithine decarboxylase in the brains of the young animals split into two ranges, a high one at control level and a low one at about one fifth of control level. As the ratio of brains with low to those with high enzyme activities correlated with the rate of postnatal mortality, the splitting of early postnatal enzyme activities was interpreted in terms of a nothing-or-all-law: beyond a certain amount of 5-azacytidine incorporated into brain DNA, gene expression was impaired to an extent not compatible with the survival of the animals.

Authors:
;
Publication Date:
Research Org.:
Institut fuer Biologie, Abteilung fuer Nuklearbiologie, Neuherberg, Germany F.R.
OSTI Identifier:
6069455
Resource Type:
Journal Article
Journal Name:
Res. Commun. Chem. Pathol. Pharmacol.; (United States)
Additional Journal Information:
Journal Volume: 56:2
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; AZO COMPOUNDS; BIOLOGICAL EFFECTS; BRAIN; BIOLOGICAL REGENERATION; CYTIDINE; NEONATES; DELAYED RADIATION EFFECTS; ENZYME ACTIVITY; BIOLOGICAL RADIATION EFFECTS; FETUSES; GENE REGULATION; GENETIC EFFECTS; MORTALITY; PREGNANCY; PRENATAL EXPOSURE; RATS; ANIMALS; AZINES; BIOLOGICAL RECOVERY; BODY; CENTRAL NERVOUS SYSTEM; HETEROCYCLIC COMPOUNDS; MAMMALS; NERVOUS SYSTEM; NUCLEOSIDES; NUCLEOTIDES; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PYRIMIDINES; RADIATION EFFECTS; RECOVERY; RIBOSIDES; RODENTS; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals; 560300 - Chemicals Metabolism & Toxicology

Citation Formats

Weber, L W, and Schmahl, W G. Postnatal pattern of ornithine decarboxylase activity reveals a disparity of rat brain regeneration capacity after prenatal X-ray or 5-azacytidine treatment. United States: N. p., 1987. Web.
Weber, L W, & Schmahl, W G. Postnatal pattern of ornithine decarboxylase activity reveals a disparity of rat brain regeneration capacity after prenatal X-ray or 5-azacytidine treatment. United States.
Weber, L W, and Schmahl, W G. 1987. "Postnatal pattern of ornithine decarboxylase activity reveals a disparity of rat brain regeneration capacity after prenatal X-ray or 5-azacytidine treatment". United States.
@article{osti_6069455,
title = {Postnatal pattern of ornithine decarboxylase activity reveals a disparity of rat brain regeneration capacity after prenatal X-ray or 5-azacytidine treatment},
author = {Weber, L W and Schmahl, W G},
abstractNote = {Pregnant Wistar rats were treated on the 15th day of gestation either with 1.4 Gy X-radiation, or with 2 X 2.5 mg 5-azacytidine per kg body weight. X-irradiation caused negligible mortality among the offspring, despite of a 35% reduction of brain weights. The course of brain ornithine decarboxylase activity exhibited two breaches within 5 days after birth, each followed by recovery to control levels. After 5-azacytidine treatment brain weights were reduced by 16% only, but two thirds of the young died within a short time after birth. During three days following birth, the activity of ornithine decarboxylase in the brains of the young animals split into two ranges, a high one at control level and a low one at about one fifth of control level. As the ratio of brains with low to those with high enzyme activities correlated with the rate of postnatal mortality, the splitting of early postnatal enzyme activities was interpreted in terms of a nothing-or-all-law: beyond a certain amount of 5-azacytidine incorporated into brain DNA, gene expression was impaired to an extent not compatible with the survival of the animals.},
doi = {},
url = {https://www.osti.gov/biblio/6069455}, journal = {Res. Commun. Chem. Pathol. Pharmacol.; (United States)},
number = ,
volume = 56:2,
place = {United States},
year = {Fri May 01 00:00:00 EDT 1987},
month = {Fri May 01 00:00:00 EDT 1987}
}