Effects of continuous phonation on /sup 133/xenon-inhalation air curves (of the kind used in deriving regional cerebral blood flow)
Regional cerebral blood flow (rCBF) may be measured with inhalation techniques that use end-expired values of radioactivity to estimate the isotope concentration in arterial blood. These end-expired data are used as an input function in a mathematical equation to derive rCBF. End-expired air is assumed normally to be in equilibrium with the arterial blood at the alveolar surface of the lung during regular (passive) breathing; this assumption may not be valid during continuous phonation. We therefore have analyzed breathing (inhalation/exhalation) patterns and end-expired radioactivity (/sup 133/Xe) during (1) speaking, (2) singing, and (3) humming of the national anthem, and also during (4) passive breathing. Statistically significant differences in breathing patterns were measured between a group of nonmusicians and two groups of musicians (singers) during the phonation tasks: The nonmusicians breathed more often (and more rapidly) and exhibited less variability in their breathing patterns than did the musicians. Notwithstanding these differences, the shapes of smoothed functions derived from the end-expired values were not influenced appreciably during phonation (except possibly during talking). The latter finding suggests that estimates of rCBF derived with these data should not be confounded seriously because of the continuous phonation.
- Research Organization:
- Univ. of Florida, Gainesville
- OSTI ID:
- 6066119
- Journal Information:
- Brain Lang.; (United States), Vol. 31:2
- Country of Publication:
- United States
- Language:
- English
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BRAIN
BLOOD FLOW
RESPIRATION
TRACER TECHNIQUES
BREATH
EQUATIONS
INHALATION
LUNGS
SPEECH
XENON 133
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CENTRAL NERVOUS SYSTEM
DAYS LIVING RADIOISOTOPES
EVEN-ODD NUCLEI
INTAKE
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
NERVOUS SYSTEM
NUCLEI
ORGANS
RADIOISOTOPES
RESPIRATORY SYSTEM
XENON ISOTOPES
551001* - Physiological Systems- Tracer Techniques