Multiple endocrine adenomatosis with Cushing's disease and the amenorrhea-galactorrhea syndrome responsive to proton beam irradiation
Multiple endocrine adenomatosis (MEA) or neoplasia is a hereditary disorder consisting of tumors of hyperplasia of several endocrine glands. In MEA-1 the pituitary, parathyroids, and pancreatic islets are most frequently involved, while in MEA-2 the thyroid (medullary carcinoma of the thyroid), parathyroids,and adrenals (pheochromocytomas) are the endocrine glands most likely to be involved. Cushings's syndrome may occur in MEA-1 and has also been found in patients with MEA-2, where the cause of Cushing's syndrome is usually ectopic ACTH production from medullary carcinoma of the thyroid. Recently, there have been reports of amenorrhea-galactorrhea syndrome in patients with MEA-1, and confirmation that hyperprolactinemia is associated with this syndrom has been found in patients with MEA-1. The present report details a patient who has been followed up for 20 years since she first presented with amenorrhea and galactorrhea. Ten years after first being seen she was noted to have Cushing's syndrom and hyperparathyroidism due to parathyroid hyperplasia. Both the amenorrhea-galactorrhea syndrome and Cushing's sydrome disappeared with proton beam irradiation to the pituitary.
- Research Organization:
- Univ. of Arkansas, Little Rock
- OSTI ID:
- 6061339
- Journal Information:
- South. Med. J.; (United States), Vol. 74:9
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CUSHING SYNDROME
RADIOTHERAPY
PHOTON BEAMS
ACTH
ADENOMAS
ADRENAL GLANDS
IRRADIATION PROCEDURES
MENSTRUATION DISORDERS
NUCLEAR MEDICINE
PANCREAS
PARATHYROID GLANDS
PITUITARY GLAND
THYROID
BEAMS
BODY
DIGESTIVE SYSTEM
DISEASES
ENDOCRINE DISEASES
ENDOCRINE GLANDS
GLANDS
HORMONES
MEDICINE
NEOPLASMS
ORGANS
PEPTIDE HORMONES
PITUITARY HORMONES
RADIOLOGY
THERAPY
550603* - Medicine- External Radiation in Therapy- (1980-)