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Title: The effect of age on systemic absorption and systemic disposition of bupivacaine after subarachnoid administration

Abstract

In order to evaluate the role of the pharmacokinetics of the age-related changes in the clinical profile of spinal anesthesia with bupivacaine, we studied the influence of age on the systemic absorption and systemic disposition of bupivacaine after subarachnoid administration in 20 male patients (22-81 yr), ASA Physical Status 1 or 2, by a stable isotope method. After subarachnoid administration of 3 ml 0.5% bupivacaine in 8% glucose, a deuterium-labeled analog (13.4 mg) was administered intravenously. Blood samples were collected for 24 h. Plasma concentrations of unlabeled and deuterium-labeled bupivacaine were determined with a combination of gas chromatography and mass fragmentography. Biexponential functions were fitted to the plasma concentration-time data of the deuterium-labeled bupivacaine. The systemic absorption was evaluated by means of deconvolution. Mono- and biexponential functions were fitted to the data of fraction absorbed versus time. The maximal height of analgesia and the duration of analgesia at T12 increased with age (r = 0.715, P less than 0.001; r = 0.640, P less than 0.01, respectively). In 18 patients the systemic absorption of bupivacaine was best described by a biexponential equation. The half-life of the slow systemic absorption process (r = -0.478; P less than 0.05) and the meanmore » absorption time (r = -0.551; P less than 0.02) decreased with age. The total plasma clearance decreased with age (r = -0.650, P less than 0.002), whereas the mean residence time and terminal half-life increased with age (r = 0.597, P less than 0.01; r = 0.503, P less than 0.05).« less

Authors:
; ; ; ;  [1]
  1. (Leiden Univ. Hospital (Netherlands))
Publication Date:
OSTI Identifier:
6061196
Resource Type:
Journal Article
Resource Relation:
Journal Name: Anesthesiology; (USA); Journal Volume: 74:2
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; ANESTHETICS; METABOLISM; ABSORPTION; AGE DEPENDENCE; BIOLOGICAL HALF-LIFE; DEUTERIUM; GAS CHROMATOGRAPHY; MASS SPECTROSCOPY; TRACER TECHNIQUES; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CHROMATOGRAPHY; DRUGS; HYDROGEN ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; LIGHT NUCLEI; NUCLEI; ODD-ODD NUCLEI; SEPARATION PROCESSES; SPECTROSCOPY; STABLE ISOTOPES; 550501* - Metabolism- Tracer Techniques

Citation Formats

Veering, B.T., Burm, A.G., Vletter, A.A., van den Hoeven, R.A., and Spierdijk, J. The effect of age on systemic absorption and systemic disposition of bupivacaine after subarachnoid administration. United States: N. p., 1991. Web. doi:10.1097/00000542-199102000-00010.
Veering, B.T., Burm, A.G., Vletter, A.A., van den Hoeven, R.A., & Spierdijk, J. The effect of age on systemic absorption and systemic disposition of bupivacaine after subarachnoid administration. United States. doi:10.1097/00000542-199102000-00010.
Veering, B.T., Burm, A.G., Vletter, A.A., van den Hoeven, R.A., and Spierdijk, J. Fri . "The effect of age on systemic absorption and systemic disposition of bupivacaine after subarachnoid administration". United States. doi:10.1097/00000542-199102000-00010.
@article{osti_6061196,
title = {The effect of age on systemic absorption and systemic disposition of bupivacaine after subarachnoid administration},
author = {Veering, B.T. and Burm, A.G. and Vletter, A.A. and van den Hoeven, R.A. and Spierdijk, J.},
abstractNote = {In order to evaluate the role of the pharmacokinetics of the age-related changes in the clinical profile of spinal anesthesia with bupivacaine, we studied the influence of age on the systemic absorption and systemic disposition of bupivacaine after subarachnoid administration in 20 male patients (22-81 yr), ASA Physical Status 1 or 2, by a stable isotope method. After subarachnoid administration of 3 ml 0.5% bupivacaine in 8% glucose, a deuterium-labeled analog (13.4 mg) was administered intravenously. Blood samples were collected for 24 h. Plasma concentrations of unlabeled and deuterium-labeled bupivacaine were determined with a combination of gas chromatography and mass fragmentography. Biexponential functions were fitted to the plasma concentration-time data of the deuterium-labeled bupivacaine. The systemic absorption was evaluated by means of deconvolution. Mono- and biexponential functions were fitted to the data of fraction absorbed versus time. The maximal height of analgesia and the duration of analgesia at T12 increased with age (r = 0.715, P less than 0.001; r = 0.640, P less than 0.01, respectively). In 18 patients the systemic absorption of bupivacaine was best described by a biexponential equation. The half-life of the slow systemic absorption process (r = -0.478; P less than 0.05) and the mean absorption time (r = -0.551; P less than 0.02) decreased with age. The total plasma clearance decreased with age (r = -0.650, P less than 0.002), whereas the mean residence time and terminal half-life increased with age (r = 0.597, P less than 0.01; r = 0.503, P less than 0.05).},
doi = {10.1097/00000542-199102000-00010},
journal = {Anesthesiology; (USA)},
number = ,
volume = 74:2,
place = {United States},
year = {Fri Feb 01 00:00:00 EST 1991},
month = {Fri Feb 01 00:00:00 EST 1991}
}