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Title: Long-term follow-up in toxic solitary autonomous thyroid nodules treated with radioactive iodine

Abstract

The long-term effects of radioiodine treatment on thyroid function in patients with a toxic solitary autonomous thyroid nodule were evaluated. Fifty-two patients received a therapeutic dose of 20 mCi of iodine-131 ({sup 131}I). Duration of follow-up was 10 +/- 4 yr. Follow-up data included a biochemical evaluation of thyroid function. The failure rate (recurrent hyperthyroidism) was 2%. The incidence of hypothyroidism was 6% and was not related to the dose per gram of nodular tissue. Oral administration of 20 mCi of radioiodine is a simple and highly effective method for the treatment of patients with a toxic autonomous thyroid nodule. The risk of development of hypothyroidism is low if extranodular uptake of {sup 131}I is prevented. This can be achieved by not treating euthyroid patients, by no longer using injections of exogenous thyroid stimulating hormone in the diagnostic work-up of the patients and by always performing radioiodine imaging shortly before treatment.

Authors:
; ;  [1]
  1. (University Hospital Nijmegen (Netherlands))
Publication Date:
OSTI Identifier:
6059074
Resource Type:
Journal Article
Journal Name:
Journal of Nuclear Medicine; (USA)
Additional Journal Information:
Journal Volume: 32:1; Journal ID: ISSN 0161-5505
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; HYPOTHYROIDISM; RADIOINDUCTION; NEOPLASMS; RADIOTHERAPY; THYROID; IODINE 131; ORAL ADMINISTRATION; PATIENTS; POST-IRRADIATION EXAMINATION; RADIATION DOSES; SIDE EFFECTS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; DAYS LIVING RADIOISOTOPES; DISEASES; DOSES; ENDOCRINE DISEASES; ENDOCRINE GLANDS; GLANDS; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPES; MEDICINE; NUCLEAR MEDICINE; NUCLEI; ODD-EVEN NUCLEI; ORGANS; RADIOISOTOPES; RADIOLOGY; THERAPY; 550604* - Medicine- Unsealed Radionuclides in Therapy- (1980-); 560161 - Radionuclide Effects, Kinetics, & Toxicology- Man

Citation Formats

Huysmans, D.A., Corstens, F.H., and Kloppenborg, P.W. Long-term follow-up in toxic solitary autonomous thyroid nodules treated with radioactive iodine. United States: N. p., 1991. Web.
Huysmans, D.A., Corstens, F.H., & Kloppenborg, P.W. Long-term follow-up in toxic solitary autonomous thyroid nodules treated with radioactive iodine. United States.
Huysmans, D.A., Corstens, F.H., and Kloppenborg, P.W. Tue . "Long-term follow-up in toxic solitary autonomous thyroid nodules treated with radioactive iodine". United States.
@article{osti_6059074,
title = {Long-term follow-up in toxic solitary autonomous thyroid nodules treated with radioactive iodine},
author = {Huysmans, D.A. and Corstens, F.H. and Kloppenborg, P.W.},
abstractNote = {The long-term effects of radioiodine treatment on thyroid function in patients with a toxic solitary autonomous thyroid nodule were evaluated. Fifty-two patients received a therapeutic dose of 20 mCi of iodine-131 ({sup 131}I). Duration of follow-up was 10 +/- 4 yr. Follow-up data included a biochemical evaluation of thyroid function. The failure rate (recurrent hyperthyroidism) was 2%. The incidence of hypothyroidism was 6% and was not related to the dose per gram of nodular tissue. Oral administration of 20 mCi of radioiodine is a simple and highly effective method for the treatment of patients with a toxic autonomous thyroid nodule. The risk of development of hypothyroidism is low if extranodular uptake of {sup 131}I is prevented. This can be achieved by not treating euthyroid patients, by no longer using injections of exogenous thyroid stimulating hormone in the diagnostic work-up of the patients and by always performing radioiodine imaging shortly before treatment.},
doi = {},
journal = {Journal of Nuclear Medicine; (USA)},
issn = {0161-5505},
number = ,
volume = 32:1,
place = {United States},
year = {1991},
month = {1}
}