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Title: Bone marrow cytology in Hiroshima atomic bomb survivors 5 years following exposure (in Japanese and English)

Abstract

Bone marrow aspiration smears obtained from 35 individuals, 5 years following expsoure to the Hiroshima atomic bomb, were intensively evaluated for radiation related cytologic abnormalities. No definite radiaton related changes were observed, but some findings were very suggestive. The most interesting of these was the occurrence of internuclear bridges joining erythroid precursors in the marrow smears of seven (20%) of the heavily exposed survivors. Although not specific it is likely that this lesion is indicative of residual stem cell damage and some degree of ineffectual erythropoiesis. The bone marrow morphologic lesions may be good markers of residual radiation damage but they are too infrequent in their occurrence to be of value as a biologic dosimeter. The findings in this study also suggest that a gradual disappearance of radiation induced late bone marrow changes continues for periods of 3 to 5 years or more following high dose acute radiation exposure.

Authors:
;
Publication Date:
Research Org.:
Radiation Effects Research Foundation, Nagasaki (Japan). Nagasaki Branch; Radiation Effects Research Foundation, Hiroshima (Japan)
OSTI Identifier:
6055420
Report Number(s):
RERF-TR-16-77
DOE Contract Number:  
EX-76-C-28-3161
Resource Type:
Technical Report
Country of Publication:
United States
Language:
Japanese and English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 59 BASIC BIOLOGICAL SCIENCES; BONE MARROW; BIOLOGICAL RECOVERY; BONE MARROW CELLS; MITOSIS; ERYTHROPOIESIS; DELAYED RADIATION EFFECTS; STEM CELLS; A-BOMB SURVIVORS; ACUTE IRRADIATION; BIOLOGICAL DOSEMETERS; CYTOLOGICAL TECHNIQUES; EXPERIMENTAL DATA; HIROSHIMA; ISOLATED VALUES; MORPHOLOGICAL CHANGES; NUCLEAR EXPLOSIONS; SUBLETHAL IRRADIATION; ACUTE EXPOSURE; ANIMAL CELLS; ASIA; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BLOOD FORMATION; BODY; CELL DIVISION; CONNECTIVE TISSUE CELLS; DATA; DATA FORMS; DOSEMETERS; EXPLOSIONS; HEMATOPOIETIC SYSTEM; INFORMATION; IRRADIATION; JAPAN; MEASURING INSTRUMENTS; NUMERICAL DATA; ORGANS; RADIATION EFFECTS; RECOVERY; SOMATIC CELLS; TISSUES; 560151* - Radiation Effects on Animals- Man; 550300 - Cytology

Citation Formats

Oesterle, S N, and Finch, S C. Bone marrow cytology in Hiroshima atomic bomb survivors 5 years following exposure. United States: N. p., 1978. Web.
Oesterle, S N, & Finch, S C. Bone marrow cytology in Hiroshima atomic bomb survivors 5 years following exposure. United States.
Oesterle, S N, and Finch, S C. Wed . "Bone marrow cytology in Hiroshima atomic bomb survivors 5 years following exposure". United States.
@article{osti_6055420,
title = {Bone marrow cytology in Hiroshima atomic bomb survivors 5 years following exposure},
author = {Oesterle, S N and Finch, S C},
abstractNote = {Bone marrow aspiration smears obtained from 35 individuals, 5 years following expsoure to the Hiroshima atomic bomb, were intensively evaluated for radiation related cytologic abnormalities. No definite radiaton related changes were observed, but some findings were very suggestive. The most interesting of these was the occurrence of internuclear bridges joining erythroid precursors in the marrow smears of seven (20%) of the heavily exposed survivors. Although not specific it is likely that this lesion is indicative of residual stem cell damage and some degree of ineffectual erythropoiesis. The bone marrow morphologic lesions may be good markers of residual radiation damage but they are too infrequent in their occurrence to be of value as a biologic dosimeter. The findings in this study also suggest that a gradual disappearance of radiation induced late bone marrow changes continues for periods of 3 to 5 years or more following high dose acute radiation exposure.},
doi = {},
url = {https://www.osti.gov/biblio/6055420}, journal = {},
number = ,
volume = ,
place = {United States},
year = {1978},
month = {11}
}

Technical Report:
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