Bone marrow cytology in Hiroshima atomic bomb survivors 5 years following exposure (in Japanese and English)
Bone marrow aspiration smears obtained from 35 individuals, 5 years following expsoure to the Hiroshima atomic bomb, were intensively evaluated for radiation related cytologic abnormalities. No definite radiaton related changes were observed, but some findings were very suggestive. The most interesting of these was the occurrence of internuclear bridges joining erythroid precursors in the marrow smears of seven (20%) of the heavily exposed survivors. Although not specific it is likely that this lesion is indicative of residual stem cell damage and some degree of ineffectual erythropoiesis. The bone marrow morphologic lesions may be good markers of residual radiation damage but they are too infrequent in their occurrence to be of value as a biologic dosimeter. The findings in this study also suggest that a gradual disappearance of radiation induced late bone marrow changes continues for periods of 3 to 5 years or more following high dose acute radiation exposure.
- Research Organization:
- Radiation Effects Research Foundation, Nagasaki (Japan). Nagasaki Branch; Radiation Effects Research Foundation, Hiroshima (Japan)
- DOE Contract Number:
- EX-76-C-28-3161
- OSTI ID:
- 6055420
- Report Number(s):
- RERF-TR-16-77
- Country of Publication:
- United States
- Language:
- Japanese and English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
BONE MARROW
BIOLOGICAL RECOVERY
BONE MARROW CELLS
MITOSIS
ERYTHROPOIESIS
DELAYED RADIATION EFFECTS
STEM CELLS
A-BOMB SURVIVORS
ACUTE IRRADIATION
BIOLOGICAL DOSEMETERS
CYTOLOGICAL TECHNIQUES
EXPERIMENTAL DATA
HIROSHIMA
ISOLATED VALUES
MORPHOLOGICAL CHANGES
NUCLEAR EXPLOSIONS
SUBLETHAL IRRADIATION
ACUTE EXPOSURE
ANIMAL CELLS
ASIA
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BLOOD FORMATION
BODY
CELL DIVISION
CONNECTIVE TISSUE CELLS
DATA
DATA FORMS
DOSEMETERS
EXPLOSIONS
HEMATOPOIETIC SYSTEM
INFORMATION
IRRADIATION
JAPAN
MEASURING INSTRUMENTS
NUMERICAL DATA
ORGANS
RADIATION EFFECTS
RECOVERY
SOMATIC CELLS
TISSUES
560151* - Radiation Effects on Animals- Man
550300 - Cytology