A connectionist model of the Drosophila blastoderm
- Columbia Univ., New York, NY (USA). Dept. of Biological Sciences
- Yale Univ., New Haven, CT (USA). Dept. of Computer Science
- Los Alamos National Lab., NM (USA). Theoretical Div.
The authors present a phenomenological modeling framework for development, and apply it to the network of segmentation genes operating in the blastoderm of Drosophila. Their purpose is to provide a systematic method for discovering and expressing correlations in experimental data on gene expression and other developmental processes. The modeling framework is based on a connectionist or neural net dynamics for biochemical regulators, coupled to grammatical rules which describe certain features of the birth, growth, and death of cells, synapses and other biological entities. They present preliminary numerical results regarding regulatory interactions between the genes Kruppel and knirps that demonstrate the potential utility of the model. 14 refs., 5 figs.
- Research Organization:
- Los Alamos National Lab., NM (USA)
- Sponsoring Organization:
- USDOD; DOE/AD
- DOE Contract Number:
- W-7405-ENG-36
- OSTI ID:
- 6039223
- Report Number(s):
- LA-UR-90-3923; CONF-9006299-1; ON: DE91004850; CNN: AFOSR-88-0240
- Resource Relation:
- Conference: Workshop on principles of organization in organisms, Santa Fe, NM (USA), 12-16 Jun 1990
- Country of Publication:
- United States
- Language:
- English
Similar Records
Three-dimensional morphology and gene expression in the Drosophila blastoderm at cellular resolution I: data acquisition pipeline
Transcription Factors Bind Thousands of Active and InactiveRegions in the Drosophila Blastoderm