Studies of the pathogenesis of arteriosclerosis induced in rats by intrarenal injection of a carcinogen, nickel subsulfide

Journal Article · Sun Jan 01 00:00:00 EST 1984 · Annals of Clinical and Laboratory Science; ()

OSTI ID:6037192

Hopfer, S M; Sunderman, Jr, F W; McCully, K S; Reid, M C; Liber, C; Spears, J R; Serur, J

Widespread arteriosclerotic lesions were detected by histological examinations of rats killed at seven or nine weeks after an intrarenal (ir) injection of nickel subsulfide (Ni3S2, 5 mg per rat). Arteriosclerotic plaques were readily visualized by administering hematoporphyrin derivative (HPD) iv to rats at 24 hours before sacrifice. At necropsy, the major arteries were inspected under ultraviolet light, revealing patches of intense HPD-fluorescence in the arterial endothelium of Ni3S2-treated rats, but not in control rats. Consistent with previous reports, the Ni3S2-treated rats developed pronounced erythrocytosis; blood hematocrit values averaged 70 +/- 4% at seven weeks after ir injection of Ni3S2 (P<0.001 vs corresponding value of 49 +/- 2% in vehicle controls). At seven weeks, blood platelet counts averaged 17% lower and serum glucose concentrations averaged 23% lower in Ni3S2-treated rats than in controls; serum lipids, lipoproteins, non-protein nitrogen constituents, electrolytes, proteins, and enzymes were not significantly affected. These findings exclude hypertension and hyperlipidemia as pathogenic factors in Ni3S2-induced arteriosclerosis. 57 references, 1 figure, 6 tables.

• Research Organization: Univ. of Connecticut School of Medicine, Farmington
• OSTI ID: 6037192
• Journal Information: Annals of Clinical and Laboratory Science; (), Vol. 14:5
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
ARTERIOSCLEROSIS
PATHOGENESIS
NICKEL
TOXICITY
ARTERIES
BLOOD PLATELETS
CARCINOGENS
ENDOTHELIUM
EXPERIMENTAL DATA
FLUORESCENCE
GLUCOSE
HEMATOPORPHYRINS
RATS
ALDEHYDES
ANIMAL TISSUES
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD VESSELS
BODY
BODY FLUIDS
CARBOHYDRATES
CARBOXYLIC ACIDS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
DATA
DISEASES
ELEMENTS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HEXOSES
INFORMATION
LUMINESCENCE
MAMMALS
MATERIALS
METALS
MONOSACCHARIDES
NUMERICAL DATA
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PIGMENTS
PORPHYRINS
RODENTS
SACCHARIDES
TISSUES
TRANSITION ELEMENTS
VASCULAR DISEASES
VERTEBRATES
560305* - Chemicals Metabolism &amp; Toxicology- Vertebrates- (-1987)
550900 - Pathology