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Title: Enzymatic protective mechanism against lipid peroxidation damage to lungs of ozone-exposed rats

Abstract

Rats were fed a vitamin E-deficient diet containing 1 to 1500 mg dl-..cap alpha..-tocopherol acetate per kilogram and then exposed to 0.7 or 0.8 ppM O/sub 3/ for 5 or 7 days. Lung homogenates were analyzed for enzyme activities. O/sub 3/ elevated thiobarbituric acid (TBA) test dreactants, primarily malonaldehyde produced by lipid peroxidation, as well as activities of GSH peroxidase, G-6-P dehydrogenase, and GSH reductase. The first three effects were partially inhibited by increasing dietary tocopherol (log basis) but the last was not affected. Compensation mechanism (homeostasis) to lipid peroxidation is: (a) increase in GSH peroxidase (increased lipid peroxide catabolism), (b) increase in GSH reductase (provides more GSH for (a)), and (c) increase in G-6-P dehydrogenase (provides more Nadph.

Authors:
;
Publication Date:
OSTI Identifier:
6036219
Resource Type:
Journal Article
Journal Name:
Lipids; (United States)
Additional Journal Information:
Journal Volume: 7
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; OZONE; BIOLOGICAL EFFECTS; BARBITURATES; BIOCHEMISTRY; ENZYMES; GLUCOSE; HOMEOSTASIS; LIPIDS; MALONIC ACID; PEROXIDES; RATS; RESPIRATORY TRACT CELLS; VITAMIN E; ALDEHYDES; ANIMAL CELLS; ANIMALS; AZINES; CARBOHYDRATES; CARBOXYLIC ACIDS; CHEMISTRY; DICARBOXYLIC ACIDS; DRUGS; HETEROCYCLIC COMPOUNDS; HEXOSES; HYPNOTICS AND SEDATIVES; MAMMALS; MONOSACCHARIDES; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANIC OXYGEN COMPOUNDS; OXYGEN COMPOUNDS; PYRIMIDINES; RODENTS; SACCHARIDES; VERTEBRATES; VITAMINS; 560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)

Citation Formats

Chow, C K, and Tappel, A L. Enzymatic protective mechanism against lipid peroxidation damage to lungs of ozone-exposed rats. United States: N. p., 1972. Web. doi:10.1007/BF02533017.
Chow, C K, & Tappel, A L. Enzymatic protective mechanism against lipid peroxidation damage to lungs of ozone-exposed rats. United States. https://doi.org/10.1007/BF02533017
Chow, C K, and Tappel, A L. Sat . "Enzymatic protective mechanism against lipid peroxidation damage to lungs of ozone-exposed rats". United States. https://doi.org/10.1007/BF02533017.
@article{osti_6036219,
title = {Enzymatic protective mechanism against lipid peroxidation damage to lungs of ozone-exposed rats},
author = {Chow, C K and Tappel, A L},
abstractNote = {Rats were fed a vitamin E-deficient diet containing 1 to 1500 mg dl-..cap alpha..-tocopherol acetate per kilogram and then exposed to 0.7 or 0.8 ppM O/sub 3/ for 5 or 7 days. Lung homogenates were analyzed for enzyme activities. O/sub 3/ elevated thiobarbituric acid (TBA) test dreactants, primarily malonaldehyde produced by lipid peroxidation, as well as activities of GSH peroxidase, G-6-P dehydrogenase, and GSH reductase. The first three effects were partially inhibited by increasing dietary tocopherol (log basis) but the last was not affected. Compensation mechanism (homeostasis) to lipid peroxidation is: (a) increase in GSH peroxidase (increased lipid peroxide catabolism), (b) increase in GSH reductase (provides more GSH for (a)), and (c) increase in G-6-P dehydrogenase (provides more Nadph.},
doi = {10.1007/BF02533017},
url = {https://www.osti.gov/biblio/6036219}, journal = {Lipids; (United States)},
number = ,
volume = 7,
place = {United States},
year = {1972},
month = {1}
}