Enzymatic protective mechanism against lipid peroxidation damage to lungs of ozone-exposed rats

doi:https://doi.org/10.1007/BF02533017

Title: Enzymatic protective mechanism against lipid peroxidation damage to lungs of ozone-exposed rats

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Abstract

Rats were fed a vitamin E-deficient diet containing 1 to 1500 mg dl-..cap alpha..-tocopherol acetate per kilogram and then exposed to 0.7 or 0.8 ppM O/sub 3/ for 5 or 7 days. Lung homogenates were analyzed for enzyme activities. O/sub 3/ elevated thiobarbituric acid (TBA) test dreactants, primarily malonaldehyde produced by lipid peroxidation, as well as activities of GSH peroxidase, G-6-P dehydrogenase, and GSH reductase. The first three effects were partially inhibited by increasing dietary tocopherol (log basis) but the last was not affected. Compensation mechanism (homeostasis) to lipid peroxidation is: (a) increase in GSH peroxidase (increased lipid peroxide catabolism), (b) increase in GSH reductase (provides more GSH for (a)), and (c) increase in G-6-P dehydrogenase (provides more Nadph.

Authors:: Chow, C K; Tappel, A L

Publication Date:: 1972-01-01

OSTI Identifier:: 6036219

Resource Type:: Journal Article

Journal Name:: Lipids; (United States)

Additional Journal Information:: Journal Volume: 7

Country of Publication:: United States

Language:: English

Subject:: 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; OZONE; BIOLOGICAL EFFECTS; BARBITURATES; BIOCHEMISTRY; ENZYMES; GLUCOSE; HOMEOSTASIS; LIPIDS; MALONIC ACID; PEROXIDES; RATS; RESPIRATORY TRACT CELLS; VITAMIN E; ALDEHYDES; ANIMAL CELLS; ANIMALS; AZINES; CARBOHYDRATES; CARBOXYLIC ACIDS; CHEMISTRY; DICARBOXYLIC ACIDS; DRUGS; HETEROCYCLIC COMPOUNDS; HEXOSES; HYPNOTICS AND SEDATIVES; MAMMALS; MONOSACCHARIDES; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANIC OXYGEN COMPOUNDS; OXYGEN COMPOUNDS; PYRIMIDINES; RODENTS; SACCHARIDES; VERTEBRATES; VITAMINS; 560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)

Citation Formats


                    Chow, C K, and Tappel, A L. Enzymatic protective mechanism against lipid peroxidation damage to lungs of ozone-exposed rats.  United States: N. p., 1972. 
        Web.  doi:10.1007/BF02533017.

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                    Chow, C K, & Tappel, A L. Enzymatic protective mechanism against lipid peroxidation damage to lungs of ozone-exposed rats.  United States.  https://doi.org/10.1007/BF02533017

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                    Chow, C K, and Tappel, A L. Sat .  
        "Enzymatic protective mechanism against lipid peroxidation damage to lungs of ozone-exposed rats".  United States.  https://doi.org/10.1007/BF02533017.

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@article{osti_6036219,

  title        = {Enzymatic protective mechanism against lipid peroxidation damage to lungs of ozone-exposed rats},

  author       = {Chow, C K and Tappel, A L},

  abstractNote = {Rats were fed a vitamin E-deficient diet containing 1 to 1500 mg dl-..cap alpha..-tocopherol acetate per kilogram and then exposed to 0.7 or 0.8 ppM O/sub 3/ for 5 or 7 days. Lung homogenates were analyzed for enzyme activities. O/sub 3/ elevated thiobarbituric acid (TBA) test dreactants, primarily malonaldehyde produced by lipid peroxidation, as well as activities of GSH peroxidase, G-6-P dehydrogenase, and GSH reductase. The first three effects were partially inhibited by increasing dietary tocopherol (log basis) but the last was not affected. Compensation mechanism (homeostasis) to lipid peroxidation is: (a) increase in GSH peroxidase (increased lipid peroxide catabolism), (b) increase in GSH reductase (provides more GSH for (a)), and (c) increase in G-6-P dehydrogenase (provides more Nadph.},

  doi          = {10.1007/BF02533017},

  url          = {https://www.osti.gov/biblio/6036219},
  journal      = {Lipids; (United States)},
number       = ,

  volume       = 7,

  place        = {United States},

  year         = {1972},

  month        = {1}

}

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