Hybridoma cells secreting a monoclonal antibody specific for 5-bromo and 5-iodoeoxyuridine and reagent for measuring cellular proliferation

Patent · Tue Jul 16 00:00:00 EDT 1985

OSTI ID:6025801

Gratzner, H G

Cells synthesizing DNA are detected in a rapid, nonradioactive assay using the monoclonal antibody reagent secreted by the hybridoma produced in accordance with the present invention. The assay is used to study DNA repair in cells that have been exposed to various environmental toxins, chemotherapeutic agents, and the like. The monoclonal antibody secreted by the hybridoma is a valuable reagent for research and diagnosis.

• Assignee: University of Miami
• Patent Number(s): US 4529700
• OSTI ID: 6025801
• Resource Relation: Patent File Date: Filed date 20 Aug 1982; Other Information: PAT-APPL-409856
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
CELL PROLIFERATION
DIAGNOSTIC TECHNIQUES
DNA REPLICATION
ENVIRONMENTAL EFFECTS
HYBRIDOMAS
MONITORING
DNA
SYNTHESIS
MONOCLONAL ANTIBODIES
ANTIBODIES
DIAGNOSTIC USES
GROWTH
PRODUCTION
REAGENTS
URIDINE
AZINES
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
NUCLEIC ACID REPLICATION
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PYRIMIDINES
RIBOSIDES
URACILS
USES
550300* - Cytology