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Title: Scintigraphic detection of carotid atherosclerosis with indium-111-labeled autologous platelets

Abstract

Using autologous platelets labeled with indium-111-oxine, we studied the localization of platelets on arterial lesions by radionuclide scintigraphy in 34 patients with suspected cerebrovascular disease. The imaging results were compared with the findings of contrast angiography in 23 patients, 16 of whom were receiving antiplatelet and/or anticoagulant drugs during the platelet imaging study. Angiography demonstrated atherosclerotic lesions at 33 sites in the extracranial arteries of 16 of these patients. There was accumulation of /sup 111/In-platelets at 20 of these sites (61%) and at three other sites without definite angiographic abnormalities. Lesions with stenoses <50% were slightly more frequent than those with greater stenosis (68% vs 45%). The frequency of true-positive scintigraphic results was slightly higher in patients not treated with antithrombotic agents than in those on such drugs (70% vs 57%). Our results suggest that imaging with /sup 111/In-labeled autologous platelets may be useful for evaluating the pathophysiologic characteristics of atherosclerotic lesions in patients with cerebrovascular disease.

Authors:
; ; ; ; ; ;
Publication Date:
Research Org.:
Washington Univ., St. Louis, MO (United States). School of Medicine
OSTI Identifier:
6012158
Resource Type:
Journal Article
Journal Name:
Circulation; (United States)
Additional Journal Information:
Journal Volume: 61:5
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ARTERIOSCLEROSIS; DIAGNOSIS; SCINTISCANNING; INDIUM 111; ANTICOAGULANTS; ARTERIES; BLOOD PLATELETS; LABELLING; NUCLEAR MEDICINE; TRACER TECHNIQUES; BETA DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BLOOD VESSELS; BODY; BODY FLUIDS; CARDIOVASCULAR DISEASES; CARDIOVASCULAR SYSTEM; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DISEASES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; HEMATOLOGIC AGENTS; INDIUM ISOTOPES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; MATERIALS; MEDICINE; MINUTES LIVING RADIOISOTOPES; NUCLEI; ODD-EVEN NUCLEI; ORGANS; RADIOISOTOPE SCANNING; RADIOISOTOPES; VASCULAR DISEASES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics

Citation Formats

Davis, H H, Siegel, B A, Sherman, L A, Heaton, W A, Naidich, T P, Joist, J R, and Welch, M J. Scintigraphic detection of carotid atherosclerosis with indium-111-labeled autologous platelets. United States: N. p., 1980. Web. doi:10.1161/01.CIR.61.5.982.
Davis, H H, Siegel, B A, Sherman, L A, Heaton, W A, Naidich, T P, Joist, J R, & Welch, M J. Scintigraphic detection of carotid atherosclerosis with indium-111-labeled autologous platelets. United States. https://doi.org/10.1161/01.CIR.61.5.982
Davis, H H, Siegel, B A, Sherman, L A, Heaton, W A, Naidich, T P, Joist, J R, and Welch, M J. 1980. "Scintigraphic detection of carotid atherosclerosis with indium-111-labeled autologous platelets". United States. https://doi.org/10.1161/01.CIR.61.5.982.
@article{osti_6012158,
title = {Scintigraphic detection of carotid atherosclerosis with indium-111-labeled autologous platelets},
author = {Davis, H H and Siegel, B A and Sherman, L A and Heaton, W A and Naidich, T P and Joist, J R and Welch, M J},
abstractNote = {Using autologous platelets labeled with indium-111-oxine, we studied the localization of platelets on arterial lesions by radionuclide scintigraphy in 34 patients with suspected cerebrovascular disease. The imaging results were compared with the findings of contrast angiography in 23 patients, 16 of whom were receiving antiplatelet and/or anticoagulant drugs during the platelet imaging study. Angiography demonstrated atherosclerotic lesions at 33 sites in the extracranial arteries of 16 of these patients. There was accumulation of /sup 111/In-platelets at 20 of these sites (61%) and at three other sites without definite angiographic abnormalities. Lesions with stenoses <50% were slightly more frequent than those with greater stenosis (68% vs 45%). The frequency of true-positive scintigraphic results was slightly higher in patients not treated with antithrombotic agents than in those on such drugs (70% vs 57%). Our results suggest that imaging with /sup 111/In-labeled autologous platelets may be useful for evaluating the pathophysiologic characteristics of atherosclerotic lesions in patients with cerebrovascular disease.},
doi = {10.1161/01.CIR.61.5.982},
url = {https://www.osti.gov/biblio/6012158}, journal = {Circulation; (United States)},
number = ,
volume = 61:5,
place = {United States},
year = {Thu May 01 00:00:00 EDT 1980},
month = {Thu May 01 00:00:00 EDT 1980}
}