Effect of antidepressants and neuroleptics on phosphoinositide turnover in human platelets

Pandey, S C; Davis, J M; Schwertz, D; Pandey, G N

Title: Effect of antidepressants and neuroleptics on phosphoinositide turnover in human platelets

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Abstract

The authors previously reported that tricyclic antidepressants and iprindole inhibit thrombin-stimulated formation of inositol-1, 4 bisphosphate (IP2) and inositol-1,4,5 triphosphate (IP3) but do not cause any change in inositol-1 phosphate (IP1). In order to examine if this decrease in IP2 and IP3 formation by antidepressants is related to the inhibition of the enzyme phospholipase C (PLC), the authors determined the effects of antidepressants and neuroleptics on the levels of 3(H) phosphotidylinositol (PI), 3(H) PI-4 phosphate (PIP), 3(H) PI-4, 5 bisphosphate (PIP2) in human platelets. The implications of the findings and their relevance to the mode of action of antidepressants are discussed.

Authors:

Pandey, S C; Davis, J M; Schwertz, D; Pandey, G N ^[1]

Illinois State Psychiatric Inst., Chicago (United States)

Publication Date:: Mon Feb 26 00:00:00 EST 1990

OSTI Identifier:: 6011814

Report Number(s):: CONF-9104107-
Journal ID: ISSN 0892-6638; CODEN: FAJOE

Resource Type:: Conference

Journal Name:: FASEB Journal (Federation of American Societies for Experimental Biology); (United States)

Additional Journal Information:: Journal Volume: 4:3; Conference: 75. annual meeting of the Federation of American Societies for Experimental Biology (FASEB), Atlanta, GA (United States), 21-25 Apr 1991; Journal ID: ISSN 0892-6638

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES; ANTIDEPRESSANTS; BIOCHEMICAL REACTION KINETICS; PSYCHOTROPIC DRUGS; BLOOD PLATELETS; HYDROLASES; INOSITOLS; MAN; TRACER TECHNIQUES; TRITIUM COMPOUNDS; ANIMALS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY FLUIDS; CARBOHYDRATES; CENTRAL NERVOUS SYSTEM AGENTS; DRUGS; ENZYMES; HYDROGEN COMPOUNDS; ISOTOPE APPLICATIONS; KINETICS; MAMMALS; MATERIALS; MONOSACCHARIDES; ORGANIC COMPOUNDS; PRIMATES; PROTEINS; REACTION KINETICS; SACCHARIDES; VERTEBRATES; 550201* - Biochemistry- Tracer Techniques

Citation Formats


                    Pandey, S C, Davis, J M, Schwertz, D, and Pandey, G N. Effect of antidepressants and neuroleptics on phosphoinositide turnover in human platelets.  United States: N. p., 1990. 
        Web.

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                    Pandey, S C, Davis, J M, Schwertz, D, & Pandey, G N. Effect of antidepressants and neuroleptics on phosphoinositide turnover in human platelets.  United States.

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                    Pandey, S C, Davis, J M, Schwertz, D, and Pandey, G N. 1990.  
        "Effect of antidepressants and neuroleptics on phosphoinositide turnover in human platelets".  United States.

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@article{osti_6011814,

  title        = {Effect of antidepressants and neuroleptics on phosphoinositide turnover in human platelets},

  author       = {Pandey, S C and Davis, J M and Schwertz, D and Pandey, G N},

  abstractNote = {The authors previously reported that tricyclic antidepressants and iprindole inhibit thrombin-stimulated formation of inositol-1, 4 bisphosphate (IP2) and inositol-1,4,5 triphosphate (IP3) but do not cause any change in inositol-1 phosphate (IP1). In order to examine if this decrease in IP2 and IP3 formation by antidepressants is related to the inhibition of the enzyme phospholipase C (PLC), the authors determined the effects of antidepressants and neuroleptics on the levels of 3(H) phosphotidylinositol (PI), 3(H) PI-4 phosphate (PIP), 3(H) PI-4, 5 bisphosphate (PIP2) in human platelets. The implications of the findings and their relevance to the mode of action of antidepressants are discussed.},

  doi          = {},

  url          = {https://www.osti.gov/biblio/6011814},
  journal      = {FASEB Journal (Federation of American Societies for Experimental Biology); (United States)},

  issn         = {0892-6638},

  number       = ,

  volume       = 4:3,

  place        = {United States},

  year         = {Mon Feb 26 00:00:00 EST 1990},

  month        = {Mon Feb 26 00:00:00 EST 1990}

}

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