In vitro generation of cytotoxic lymphocytes against radiation-and radiation leukemia virus-induced tumors. III. Suppression of anti-tumor immunity in vitro by lymphocytes of mice undergoing radiation leukemia virus-induced leukemogenesis

Journal Article · Mon Dec 01 00:00:00 EST 1980 · J. Exp. Med.; (United States)

DOI:https://doi.org/10.1084/jem.152.6.1473· OSTI ID:6008081

Yefenof, E; Meidav, A; Kedar, E

Adult C57BL/6 mice exposed to fractionated irradiation or inoculated with the radiation leukemia virus (RadLV), develop high incidence (80 to 100%) of lymphatic leukemias within 3 to 6 months. RadLV-induced lymphomas can elicit cytotoxic responses in vitro in lymphocytes of preimmunized syngeneic mice. As soon as 5 d after RadLV inoculation, and during the entire leukemogenic process, suppressor T cells are detectable in the spleen that are capable of specifically abrogating generation of syngeneic anti-tumor cytotoxic cells in vitro. Mice exposed to fractionated x irradiation do not develop suppressor cells. These findings suggest that although RadLV has been isolated from radiation-induced leukemias, x-ray- and RadLV-induced leukemogenesis do not seem to involve a common viral etilogy, and that induction of suppressor cells during RadLV leukemogenesis may be essential for tumor progression.

• OSTI ID: 6008081
• Journal Information: J. Exp. Med.; (United States), Vol. 152:6
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
CARCINOGENESIS
IMMUNOLOGY
LEUKEMIA
ETIOLOGY
RADIOINDUCTION
LYMPHOCYTES
LYMPHOMAS
DOSE-RESPONSE RELATIONSHIPS
FRACTIONATED IRRADIATION
IN VITRO
LEUKEMIA VIRUSES
MICE
ANIMAL CELLS
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DISEASES
HEMIC DISEASES
IRRADIATION
LEUKOCYTES
MAMMALS
MATERIALS
MICROORGANISMS
NEOPLASMS
ONCOGENIC VIRUSES
PARASITES
PATHOGENESIS
RODENTS
SOMATIC CELLS
VERTEBRATES
VIRUSES
560152* - Radiation Effects on Animals- Animals
550300 - Cytology