In vivo proton nuclear magnetic resonance imaging and spectroscopy studies of halocarbon-induced liver damage

Journal Article · Wed Feb 01 00:00:00 EST 1989 · Magnet. Reson. Med.; (United States)

DOI:https://doi.org/10.1002/mrm.1910090208· OSTI ID:5997544

Brauer, M; Towner, R A; Renaud, I; Janzen, E G; Foxall, D L

Proton magnetic resonance imaging and localized NMR spectroscopy were used to study the rat liver in situ. Respiratory gating was used in both the imaging and the localized spectroscopy studies to control for the movement of the upper abdomen of the rat during breathing. After administration of carbon tetrachloride, bromotrichloromethane, or halothane, localized regions of high proton signal intensity were observed in the NMR images of the liver. Localized (VOSY) proton NMR spectra from within these regions indicated that the increase in a signal intensity was due to a longer T2 relaxation time for the water resonance, indicating acute edema in the region of tissue damage.

• Research Organization: Univ. of Guelph, Ontario (Canada)
• OSTI ID: 5997544
• Journal Information: Magnet. Reson. Med.; (United States), Vol. 9:2
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
LIVER
NMR IMAGING
CARBON TETRACHLORIDE
CHLOROFORM
EDEMA
IN VIVO
LIPIDS
NMR SPECTRA
NUCLEAR MAGNETIC RESONANCE
PROTONS
RATS
WATER
ANIMALS
BARYONS
BODY
CHLORINATED ALIPHATIC HYDROCARBONS
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
ELEMENTARY PARTICLES
FERMIONS
GLANDS
HADRONS
HALOGENATED ALIPHATIC HYDROCARBONS
HYDROGEN COMPOUNDS
MAGNETIC RESONANCE
MAMMALS
NUCLEONS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
PATHOLOGICAL CHANGES
RESONANCE
RODENTS
SPECTRA
SYMPTOMS
VERTEBRATES
550600* - Medicine