skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Left ventricular performance during exercise in patients with left bundle branch block: evaluation by gated radionuclide ventriculography

Abstract

To investigate changes in left ventricular (LV) function during exercise in patients with left bundle branch block (LBBB), 22 patients without a history or physical findings of previous myocardial infarction or LV dysfunction were studied by gated radionuclide ventriculography (GRNV) at rest and during bicycle exercise. Coronary arteriography demonstrated greater than 75% diameter narrowing of at least one coronary artery in nine patients. Of the remaining 13 patients, GRNV demonstrated wall motion abnormalities in seven patients either at rest or with exercise. During exercise, mean ejection fraction (EF) did not increase in patients without coronary artery disease (CAD). Patients with CAD had a 12-point fall in mean EF with exercise. Researchers conclude that LV reserve, as demonstrated by ability to increase EF with exercise, is impaired in patients with LBBB even in the absence of CAD or other underlying cardiac disease and that standard GRNV criteria to exclude the presence of CAD (a greater than five-point increase in EF with exercise and normal wall motion) are not strictly applicable in screening patients with LBBB.

Authors:
; ; ; ;
Publication Date:
Research Org.:
Section of Cardiology, St. Luke's Episcopal Hospital, Fresno, CA
OSTI Identifier:
5997195
Resource Type:
Journal Article
Resource Relation:
Journal Name: Am. Heart J.; (United States); Journal Volume: 105:1
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 59 BASIC BIOLOGICAL SCIENCES; HEART; DYNAMIC FUNCTION STUDIES; TECHNETIUM 99; DIAGNOSTIC USES; BLOOD PRESSURE; COMPARATIVE EVALUATIONS; CORONARIES; EXERCISE; ISOMERIC NUCLEI; MYOCARDIAL INFARCTION; PATIENTS; USA; ARTERIES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BLOOD VESSELS; BODY; CARDIOVASCULAR DISEASES; CARDIOVASCULAR SYSTEM; DISEASES; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; NORTH AMERICA; NUCLEI; ODD-EVEN NUCLEI; ORGANS; RADIOISOTOPES; TECHNETIUM ISOTOPES; USES; YEARS LIVING RADIOISOTOPES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics; 551001 - Physiological Systems- Tracer Techniques

Citation Formats

Rowe, D.W., De Puey, E.G., Sonnemaker, R.E., Hall, R.J., and Burdine, J.A. Left ventricular performance during exercise in patients with left bundle branch block: evaluation by gated radionuclide ventriculography. United States: N. p., 1983. Web. doi:10.1016/0002-8703(83)90280-6.
Rowe, D.W., De Puey, E.G., Sonnemaker, R.E., Hall, R.J., & Burdine, J.A. Left ventricular performance during exercise in patients with left bundle branch block: evaluation by gated radionuclide ventriculography. United States. doi:10.1016/0002-8703(83)90280-6.
Rowe, D.W., De Puey, E.G., Sonnemaker, R.E., Hall, R.J., and Burdine, J.A. Sat . "Left ventricular performance during exercise in patients with left bundle branch block: evaluation by gated radionuclide ventriculography". United States. doi:10.1016/0002-8703(83)90280-6.
@article{osti_5997195,
title = {Left ventricular performance during exercise in patients with left bundle branch block: evaluation by gated radionuclide ventriculography},
author = {Rowe, D.W. and De Puey, E.G. and Sonnemaker, R.E. and Hall, R.J. and Burdine, J.A.},
abstractNote = {To investigate changes in left ventricular (LV) function during exercise in patients with left bundle branch block (LBBB), 22 patients without a history or physical findings of previous myocardial infarction or LV dysfunction were studied by gated radionuclide ventriculography (GRNV) at rest and during bicycle exercise. Coronary arteriography demonstrated greater than 75% diameter narrowing of at least one coronary artery in nine patients. Of the remaining 13 patients, GRNV demonstrated wall motion abnormalities in seven patients either at rest or with exercise. During exercise, mean ejection fraction (EF) did not increase in patients without coronary artery disease (CAD). Patients with CAD had a 12-point fall in mean EF with exercise. Researchers conclude that LV reserve, as demonstrated by ability to increase EF with exercise, is impaired in patients with LBBB even in the absence of CAD or other underlying cardiac disease and that standard GRNV criteria to exclude the presence of CAD (a greater than five-point increase in EF with exercise and normal wall motion) are not strictly applicable in screening patients with LBBB.},
doi = {10.1016/0002-8703(83)90280-6},
journal = {Am. Heart J.; (United States)},
number = ,
volume = 105:1,
place = {United States},
year = {Sat Jan 01 00:00:00 EST 1983},
month = {Sat Jan 01 00:00:00 EST 1983}
}